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Cheon: The Regulation of Intestinal Epithelial Necroptosis and Terminal Ileitis Mediated by Apoptosis through Caspase-8
Research Update
The Korean Journal of Gastroenterology

The Korean Journal of Gastroenterology 2012; 59(3): 262-263.

Published online: 21 March 2012

DOI: https://doi.org/10.4166/kjg.2012.59.3.262

The Regulation of Intestinal Epithelial Necroptosis and Terminal Ileitis Mediated by Apoptosis through Caspase-8

Jae Hee Cheon

Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

Correspondence to: Jae Hee Cheon, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea. Tel: +82-2-2228-1990, Fax: +82-2-393-6884, GENIUSHEE@yuhs.ac

Copyright © 2012 The Korean Society of Gastroenterology

(open-access):

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Notes

Financial support: None.

Conflict of interest: None.

References

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2. Nenci A, Becker C, Wullaert A, et al. Epithelial NEMO links innate immunity to chronic intestinal inflammation. Nature. 2007. 446:557–561.
3. Günther C, Martini E, Wittkopf N, et al. Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis. Nature. 2011. 477:335–339.
4. Wehkamp J, Stange EF. Paneth's disease. J Crohns Colitis. 2010. 4:523–531.
5. Vandenabeele P, Galluzzi L, Vanden Berghe T, Kroemer G. Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat Rev Mol Cell Biol. 2010. 11:700–714.
6. Welz PS, Wullaert A, Vlantis K, et al. FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation. Nature. 2011. 477:330–334.
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