Selective role of Mediator tail module in the transcription of highly regulated genes in yeast

Suraiya A. Ansari Laboratory of Molecular Genetics; Wadsworth Center; New York State Department of Health; Albany, NY USACorrespondencesansari@wadsworth.org randall.morse@wadsworth.org

Randall H. Morse Laboratory of Molecular Genetics; Wadsworth Center; New York State Department of Health; Albany, NY USA; Department of Biomedical Science; University at Albany School of Public Health; Albany, NY USACorrespondencesansari@wadsworth.org randall.morse@wadsworth.org

Abstract

The tail module subunits of Mediator complex are targets of activators both in yeast and metazoans. Here we discuss recent evidence from studies in yeast for tail module specificity for SAGA-dependent, TATA-containing genes including highly regulated stress response genes, and for independent recruitment and function of the tail module.

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Acknowledgments

We thank Joe Wade for a critical reading of the manuscript. This work was supported by NSF grant MCB0949722.

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Selective role of Mediator tail module in the transcription of highly regulated genes in yeast

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Selective role of Mediator tail module in the transcription of highly regulated genes in yeast

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