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    Korean J Urol. 2007 Mar;48(3):356-358. Korean.
    Published online Mar 31, 2007.
    https://doi.org/10.4111/kju.2007.48.3.356
    Copyright © 2007 The Korean Urological Association
    Case Report

    Primary Bladder Signet Ring Cell Carcinoma Extended to Prostate

    Je Hyeong Woo, Hyun Jung Park, Eun Kyung Kim,1 Jeong Yoon Kang, Jeong Yun Jeong and Tag Keun Yoo
      • Department of Urology, Eulji University School of Medicine, Seoul, Korea.
      • 1Department of Pathology, Eulji University School of Medicine, Seoul, Korea.
    • Corresponding author (Email: ytk5202@eulji.or.kr )
    Received November 10, 2006; Accepted November 30, 2006.

    Abstract

    A primary signet ring cell carcinoma (PSRCC) of the urinary bladder is a rare variant of a mucin-producing adenocarcinoma. The prognosis of a PSRCC is poor, as silent progression in a linitis platica fashion leads to delayed diagnosis. Herein, the case of a PSRCC of the bladder, which extended to the prostate, which was treated with a cystoprostatectomy, is reported.

    Keywords
    Carcinoma; signet ring cell; Bladder

    Figures

    Fig. 1
    (A) Prostatic urethral mass on cystoscopy. (B) Normal prostatic glands are seen on the left side, with dense tumor cells seen on the right side (H&E, ×100).

    Fig. 2
    Post-transurethral resection (TUR) pelvic computer tomography showing multiple bladder wall thickening (A) and a filling defect of the left bladder base (B).

    Fig. 3
    (A) Microscopic findings of a signet ring cell carcinoma. A histological examination revealed a predominance of cancer cells forming abundant mucin. Periodic acid-Schiff stain was positive (×400). (B) Prostate-specific antigen (PSA) stain showing no staining of the cancer cell (×100).

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    MeSH Terms
    Adenocarcinoma
    Carcinoma, Signet Ring Cell*
    Delayed Diagnosis
    Prognosis
    Prostate*
    Urinary Bladder*
    Metrics
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