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    Korean J Urol. 2006 Dec;47(12):1367-1370. Korean.
    Published online Dec 31, 2006.
    https://doi.org/10.4111/kju.2006.47.12.1367
    Copyright © 2006 The Korean Urological Association
    Case Report

    Xanthogranulomatous Pyelonephritis in an Infant

    Ha Na Lee, Kyu Hyun Kim, In Wook Ryu, Min Cheol Han and Woo Sik Chung
      • Department of Urology, Ewha Womans University College of Medicine, Seoul, Korea.
    • Corresponding author (Email: woochung@ewha.ac.kr )
    Received July 18, 2006; Accepted August 09, 2006.

    Abstract

    Xanthogranulomatous pyelonephritis (XGP) is an uncommon, severe, chronic infection of the kidney, which results in the normal renal parenchyma being replaced by characteristic lipid-laden macrophages (foam cells). It can occur at any age, but is extremely rare in children. Herein, the case of a 6-month-3-week-old girl with XGP, pre-operatively diagnosed with a Wilms' tumor, is reported. This is the youngest age of any patient with such a condition reported in the Korean literatures. Excretory urography, abdominal sonogram, computed tomogram and magnetic resonance imaging revealed a right renal round mass, without any calcifications. Her pathological findings after a radical nephrectomy revealed XGP.

    Keywords
    Xanthogranulomatous pyelonephritis; Infant

    Figures

    Fig. 1
    Radiological findings. (A) Ultrasonography of the abdomen shows a well demarcated heterogeneous echogenic lesion with a thin echogenic rim in the middle portion of the slightly enlarged right kidney. (B) Postcontrast enhancement of abdominal computerized tomography demonstrates a well demarcated, round soft tissue density mass at the upper pole of the right kidney. (C) T1-weighted image, coronal section of a magnetic resonance image shows a heterogeneous, diffuse enhancement and irregularly shaped low signal intensity mass at the anterior aspect of the middle portion of the right kidney.

    Fig. 2
    Microscopic findings of the specimen reveal extensive pyelonephritis, granulomas, atrophied glomerulus and tubules, and lipid-laden macrophages (foam cells) (black arrow) and plasma cells (white arrow) (H&E, ×200).

    References

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    MeSH Terms
    Child
    Female
    Humans
    Infant*
    Kidney
    Macrophages
    Magnetic Resonance Imaging
    Nephrectomy
    Pyelonephritis, Xanthogranulomatous*
    Urography
    Wilms Tumor
    Metrics
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