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Kinetic and Kinematic Analysis of Gait in Type IV Osteogenesis Imperfecta Patients: A Comparative Study

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Abstract

Background

Osteogenesis imperfecta (OI) is a genetic connective tissue disorder characterized by skeletal deformity and increased risk of fracture. Independent mobility is of concern for OI patients as it is associated with the quality of life. The present study investigates the variation of kinetic and kinematic gait parameters of type IV OI subjects and compares them with age-matched healthy subjects.

Materials and Methods

Gait analysis is performed on five type IV OI patients and six age-matched normal subjects. Spatiotemporal, kinematic, and kinetic data are obtained using Helen Hayes marker placement protocol.

Results

The results indicate an imprecise double-humped profile for vertical ground reaction force (GRF) with reduced ankle push off power and walking speed for OI subjects. Moreover, a comparison of vertical GRFs in OI subjects with that of healthy subjects suggests lower values for the former. The results encourage and motivate for further investigation with a bigger set of subjects.

Conclusion

This information may be useful in developing a better understanding of pathological gait in type IV OI subjects, which ultimately helps the design of subject-specific implants, surgical preplanning, and rehabilitation.

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References

  1. Sillence DO, Rimoin DL. Classification of osteogenesis imperfect. Lancet 1978;1:1041–2.

    Article  CAS  Google Scholar 

  2. Forlino A, Cabral WA, Barnes AM, Marini JC. New perspectives on osteogenesis imperfecta. Nat Rev Endocrinol 2011;7:540–57.

    Article  CAS  Google Scholar 

  3. Forlino A, Marini JC. Osteogenesis imperfecta. Lancet 2016;387:1657–71.

    Article  CAS  Google Scholar 

  4. Sillence DO, Senn A, Danks DM. Genetic heterogeneity in osteogenesis imperfecta. J Med Genet 1979;16:101–16.

    Article  CAS  Google Scholar 

  5. Harris GF, Smith PA, editors. Pediatric Gait: A New Millennium in Clinical Care and Motion Analysis Technology. Institute of Electrical and Electronics Engineers (IEEE); 2000.

  6. Rauch F, Glorieux FH. Osteogenesis imperfecta, current and future medical treatment. Am J Med Genet C Semin Med Genet 2005;139C: 31–7.

    Article  CAS  Google Scholar 

  7. Rauch F, Travers R, Glorieux FH. Pamidronate in children with osteogenesis imperfecta: Histomorphometric effects of long term therapy. J Clin Endocrinol Metab 2006;91:511–6.

    Article  CAS  Google Scholar 

  8. Rauch F, Travers R, Plotkin H, Glorieux FH. The effects of intravenous pamidronate on the bone tissue of children and adolescents with osteogenesis imperfecta. J Clin Invest 2002;110:1293–9.

    Article  CAS  Google Scholar 

  9. Trejo P, Rauch F. Osteogenesis imperfecta in children and adolescents-new developments in diagnosis and treatment. Osteoporos Int 2016;27:3427–37.

    Article  CAS  Google Scholar 

  10. Weber M, Roschger P, Fratzl-Zelman N, Schöberl T, Rauch F, Glorieux FH, et al. Pamidronate does not adversely affect bone intrinsic material properties in children with osteogenesis imperfecta. Bone 2006;39:616–22.

    Article  CAS  Google Scholar 

  11. Murray D, Young BH. Osteogenesis imperfecta treated by fixation with intramedullary rod. South Med J 1960;53:1142–3.

    Article  CAS  Google Scholar 

  12. Tiley F, Albright JA. Osteogenesis imperfecta: Treatment by multiple osteotomy and intramedullary rod insertion. Report on thirteen patients. J Bone Joint Surg Am 1973;55:701–13.

    Article  CAS  Google Scholar 

  13. Stockley I, Bell MJ, Sharrard WJ. The role of expanding intramedullary rods in osteogenesis imperfecta. J Bone Joint Surg Br 1989;71:422–7.

    Article  CAS  Google Scholar 

  14. Moreira CLM, Lima MAF, Cardoso MHC, Gomes Junior SCS, Lopes PB, Llerena Junior JC. Independent walk in osteogenesis imperfecta. Acta Ortop Bras 2011;19:312–5.

    Article  Google Scholar 

  15. Vanz AP, van de Sande Lee J, Pinheiro B, Zambrano M, Brizola E, da Rocha NS, et al. Health-related quality of life of children and adolescents with osteogenesis imperfecta: A cross-sectional study using pedsQL™. BMC Pediatr 2018;18:95.

    Article  Google Scholar 

  16. Hill CL, Baird WO, Walters SJ. Quality of life in children and adolescents with osteogenesis imperfecta: A qualitative interview based study. Health Qual Life Outcomes 2014;12:54.

    Article  Google Scholar 

  17. Donnan L. Preoperative assessment for complex lower limb deformity. J Pediatr Orthop 2017;37 Suppl 2:S12–S17.

    Article  Google Scholar 

  18. Feng J, Wick J, Bompiani E, Aiona M. Applications of gait analysis in pediatric orthopaedics. Curr Orthop Pract 2016;27:455–64.

    Article  Google Scholar 

  19. Lofterød B, Terjesen T, Skaaret I, Huse AB, Jahnsen R. Preoperative gait analysis has a substantial effect on orthopedic decision making in children with cerebral palsy: Comparison between clinical evaluation and gait analysis in 60 patients. Acta Orthop 2007;78:74–80.

    Article  Google Scholar 

  20. Thomason P, Rodda J, Sangeux M, Selber P, Graham K. Management of children with ambulatory cerebral palsy: An evidence-based review. Commentary by hugh Williamson gait laboratory staff. J Pediatr Orthop 2012;32 Suppl 2:S182–6.

    Article  Google Scholar 

  21. Graf A, Hassani S, Krzak J, Caudill A, Flanagan A, Bajorunaite R, et al. Gait characteristics and functional assessment of children with type I osteogenesis imperfecta. J Orthop Res 2009;27:1182–90.

    Article  Google Scholar 

  22. Garman CR, Graf A, Krzak J, Caudill A, Smith P, Harris G, et al. Gait deviations in children with osteogenesis imperfecta type I. J Pediatr Orthop 2017; DOI: 10.1097/BPO.0000000000001062, PMID: 28777275 (Ahead of print).

  23. Graf A, Krzak J, Caudill A, Flanagan A, Smith P, Harris GF. Quantitative assessment of children with osteogenesis imperfecta. In: Smith P, Rauch F, Harris G, editors. Transitional Care in Osteogenesis Imperfecta: Advances in Biology, Technology, and Clinical Practice, 1st ed. Chicago: Shriners Hospitals for Children-Chicago; 2016. p. 217–32.

    Google Scholar 

  24. Samson MM, Crowe A, de Vreede PL, Dessens JA, Duursma SA, Verhaar HJ, et al. Differences in gait parameters at a preferred walking speed in healthy subjects due to age, height and body weight. Aging (Milano) 2001;13:16–21.

    CAS  Google Scholar 

  25. Modenese L, Phillips ATM. Prediction of hip contact forces and muscle activations during walking at different speeds. Multibody Syst Dyn 2012;28:157–68.

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Physical and Rehabilitation Medicine, Post Graduate Institute of Medical Research and Education, Chandigarh, India

    Sandip R. Dhole & Mandeep Singh Dhillon

  2. Department of Orthopaedics, Post Graduate Institute of Medical Research and Education, Chandigarh, 160 012, India

    Nirmal Raj Gopinathan & Mandeep Singh Dhillon

  3. Department of Endocrinology, Post Graduate Institute of Medical Research and Education, Chandigarh, India

    Vandana Dhiman

  4. Department of Mechanical Engineering, Indian Institute of Technology Ropar, Rupnagar, Punjab, India

    Subham Badhyal, Anshu Dhar Jayal & Jitendra Prasad

Authors
  1. Subham Badhyal
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  2. Sandip R. Dhole
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  3. Nirmal Raj Gopinathan
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  4. Mandeep Singh Dhillon
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  5. Vandana Dhiman
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  6. Anshu Dhar Jayal
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  7. Jitendra Prasad
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Correspondence to Nirmal Raj Gopinathan.

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Badhyal, S., Dhole, S.R., Gopinathan, N.R. et al. Kinetic and Kinematic Analysis of Gait in Type IV Osteogenesis Imperfecta Patients: A Comparative Study. JOIO 53, 560–566 (2019). https://doi.org/10.4103/ortho.IJOrtho_291_18

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  • DOI: https://doi.org/10.4103/ortho.IJOrtho_291_18

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