CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2011; 32(01): 3-11
DOI: 10.4103/0971-5851.81883
REVIEW ARTICLE

Epidemiological review of gastric cancer in India

Rajesh P Dikshit
Department of Epidemiology, Tata Memorial Hospital, Mumbai, India
,
Garima Mathur
Department of Epidemiology, Tata Memorial Hospital, Mumbai, India
,
Sharayu Mhatre
Department of Epidemiology, Tata Memorial Hospital, Mumbai, India
,
B B Yeole
Population Based Cancer Registry, Indian Cancer Society, Mumbai, Maharashtra, India
› Author Affiliations
Source of Support Nil.

Abstract

Stomach cancer is the one of the leading cause of cancer in southern region of India. Its incidence is decreasing worldwide yet on global scale stomach cancer remains one of the most common causes of cancer death. Etiology of gastric cancer includes Helicobacter pylori infection, diet and lifestyle, tobacco, alcohol and genetic susceptibility. In this review, we tried to find the contribution of Indian scientist in understanding the descriptive and observational epidemiology of stomach cancer. PubMed was used as a search platform using key words such as "stomach cancer, treatment, clinical characteristics, stomach cancer outcome, epidemiology, etiological factor and their corresponding Mesh terms were used in combination with Boolean operators OR, AND". Most of the reported studies on gastric cancer from India are case report or case series and few are case-control studies. Indian studies on this topic are limited and have observed H. pylori infection, salted tea, pickled food, rice intake, spicy food, soda (additive of food), tobacco and alcohol as risk factors for gastric cancer. More research is required to understand the etiology, develop suitable screening test, to demarcate high-risk population and to develop and evaluate the effect of primary prevention programs.



Publication History

Article published online:
16 August 2021

© 2011. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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  • References

  • 1 Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. GLOBOCAN 2008, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10. Lyon, France: International Agency for Research on Cancer; 2010. Available from: http://www.globocan.iarc.fr Peter Boyle and Bernard Levin (ed.) World Cancer Report, 2008 IARC; 2008.
  • 2 Mohandas KM, Jagannath P. Epidemiology of digestive tract cancers in India. VI. Projected burden in the new millennium and the need for primary prevention. Indian J Gastroenterol 2000;19:74-8.
  • 3 Yeole BB. Trends in cancer incidence in esophagus, stomach, colon, rectum and liver in males in India. Asian Pac J Cancer Prev 2008;9:97-100.
  • 4 Bombay Cancer Registry. Cancer Incidence and Mortality in greater Mumbai, 1994. Report of Bombay Cancer Registry Mumbai, India 1998.
  • 5 Bombay Cancer Registry. Cancer Incidence and Mortality in greater Mumbai, 2005. Report of Bombay Cancer Registry Mumbai, India, 2009.
  • 6 Hohenbergos P, Gretschel S. Gastric cancer. Lancet 2003;362:305-15.
  • 7 A report by National Cancer registry Programme. Time trends in Cancer Incidence rates 1982-2005; Indian council of medical research, 2009.
  • 8 Sankaranarayanan R, Swaminathan R, Lucas E. Cancer survival in Africa, Asia, Caribbean and Central America: SURVCAN. Lyon: IARC Scientific publication international agency for research on cancer; 2010.
  • 9 Sankaranarayanan R, Swaminathan R, Brenner H, Chen K, Chia KS, Chen JG, et al. Cancer survival in Africa, Asia, and Central America: A population-based study. Lancet Oncol 2010;11:165-73.
  • 10 IARC. IARC Monographs on the Evaluation of carcinogenic Risks to Humans, Schitosomes, Liver Flukes, and Helicobacter pylori. Vol. 61. Lyon, France: International Agency for Research on Cancer; 1994.
  • 11 Cheng SC, Sanderson CR, Waters TE, Goodwin CS. Compylobacter pyloridis in patients with gastric carcinoma. Med J Aust 1987;147:202-3.
  • 12 Loffeld RJ, Williams I, Flendrig JA, Arends JW. Helicobacter pylori and gastric carcinoma. Histopathology 1990;17:537-41.
  • 13 Danesh J. Helicobacter pylori infection and gastric cancer: Systematic review of epidemiological studies. Aliment Pharmacol Ther 1999;13:851-6.
  • 14 Saxena A, Nath Prasad K, Chand Ghoshal U, Krishnani N, Roshan Bhagat M, Husain N. Association of Helicobacter pylori and Epstein-Barr virus with gastric cancer and peptic ulcer disease. Scand J Gastroenterol 2008;43:669-74.
  • 15 Ghoshal UC, Tiwari S, Dhingra S, Pandey R, Ghoshal U, Tripathi S, et al. Frequency of Helicobacter pylori and CagA antibody in patients with gastric neoplasms and controls: The Indian enigma. Dig Dis Sci 2008;53:1215-22.
  • 16 Misra V, Misra SP, Singh MK, Singh PA, Dwivedi M. Prevalence of H. pylori in patients with gastric cancer. Indian J Pathol Microbiol 2007;50:702-7.
  • 17 Khanna AK, Seth P, Nath G, Dixit VK, Kumar M. Correlation of Helicobacter pylori and gastric carcinoma. J Postgrad Med 2002;48:27-8.
  • 18 Phukan RK, Narain K, Zomawia E, Hazarika NC, Mahanta J. Dietary habits and stomach cancer in Mizoram, India J Gastroenterol 2006;41:418-24.
  • 19 Parkin DM. The global health burden of infection-associated cancers in the year 2002. Int J Cancer 2006;118:3030-44.
  • 20 World cancer research fund/American institute for cancer research: Food, nutrition, physical activity and the prevention of cancer: A global perspective. Washington DC: American institute of cancer research; 2007.
  • 21 Correa P. A human model of gastric carcinogenesis. Cancer Res 1988;48:3554-60.
  • 22 Sumathi B, Ramalingam S, Navaneethan U, Jayanthi V. Risk factors for gastric cancer in South India. Singapore Med J 2009;50:147-51.
  • 23 Mathew A, Gangadharan P, Varghese C, Nair MK. Diet and stomach cancer: A case-control study in South India. Eur J Cancer Prev 2000;9:89-97.
  • 24 Rao DN, Ganesh B, Dinshaw KA, Mohandas KM. A case-control study of stomach cancer in Mumbai, India. Int J Cancer 2002;99:727-31.
  • 25 Wang XQ, Terry PD, Yan H. Review of salt consumption and stomach cancer risk: Epidemiological and biological evidence. World J Gastroenterol 2009;15:2204-13.
  • 26 Siddiqui M, Kumar R, Fazili S, Spiegelhaldar B, Preussmann R. Increased exposure to dietary amines and nitrates in a population at high risk of esophageal and gastric cancer in Kashmir (India). Carcinogenesis 1992;13:1331-5.
  • 27 Shaffey O, Eriksen M, Ross H, Mackay J, editors. The Tobacco Atlas. 3 rd ed. Georgia, USA: American Cancer society; 2009.
  • 28 Gajalakshmi CK, Shanta V. Lifestyle and risk of stomach cancer: A hospital-based case-control study. Int J Epidemiol 1996;25:1146-53.
  • 29 Phukan RK, Zomawia E, Narain K, Hazarika NC, Mahanta J. Tobacco use and stomach cancer in Mizoram, India. Cancer Epidemiol Biomarkers Prev 2005;14:1892-6.
  • 30 El-Omar EM, Carrington M, Chow WH, McMoll KE, Bream JH, Young HA, et al. Interleukin-1 polymorphism associated with increased risk of gastric cancer. Nature 2000;404:398-402.
  • 31 Hold GL, Rabkin CS, Chow WH, Smith MG, Gammon MD, Risch HA, et al. A functional polymorphism of toll like receptor 4 gene increases risk of gastric carcinoma and its precursors. Gasteroenterology 2007;132:905-12.
  • 32 Magnusson PK, Enroth H, Eriksson I, Held M, Nyren O, Engstrand L, et al. Gastric cancer and human leukocyte antigen: Distinct DQ and DR alleles are associated with the development of gastric cancer and infection by helicobactor pylori. Cancer Res 2001;61:2684-9.
  • 33 Li H, Chen XL, Li HQ. Polymorphism of CYPIA1 and GSTM1 genes associated with susceptibility of gastric cancer in Shandong province of China. World J Gasteroenterol 2005;11:5757-62.
  • 34 Gonzalez CA, Sala N, Capella G. Genetic susceptibility and gastric cancer risk. Int J Cancer 2002;100:249-60.
  • 35 Shen H, Xu Y, Qian Y, Yu R, Qin Y, Zhou L, et al. Polymorphism of DNA repair gene XRCC1 and risk of gastric cancer in Chinese population. Int J Cancer 2000;88:601-6.
  • 36 Malik MA, Upadhyay R, Mittal RD, Zargar SA, Modi DR, Mittal B. Role of xenobiotic-metabolizing enzyme gene polymorphisms and interactions with environmental factors in susceptibility to gastric cancer in Kashmir Valley. J Gastrointest Cancer 2009;40:26-32.
  • 37 Tripathi S, Ghoshal U, Ghoshal UC, Mittal B, Krishnani N, Chourasia D, et al. Gastric carcinogenesis: Possible role of polymorphisms of GSTM1, GSTT1, and GSTP1 genes. Scand J Gastroenterol 2008;43:431-9.
  • 38 Prasad KN, Saxena A, Ghoshal UC, Bhagat MR, Krishnani N. Analysis of Pro12Ala PPAR gamma polymorphism and Helicobacter pylori infection in gastric adenocarcinoma and peptic ulcer disease. Ann Oncol 2008;19:1299-303.
  • 39 Saxena A, Prasad KN, Ghoshal UC, Bhagat MR, Krishnani N, Husain N. Polymorphism of -765G>C COX-2 is a risk factor for gastric adenocarcinoma and peptic ulcer disease in addition to H pylori infection: A study from northern India. World J Gastroenterol 2008;14:1498-503.
  • 40 Malik MA, Upadhyay R, Modi DR, Zargar SA, Mittal B. Association of NAT2 gene polymorphisms with susceptibility to esophageal and gastric cancers in the Kashmir Valley. Arch Med Res 2009;40:416-23.
  • 41 Kumar S, Kumar A, Dixit VK. Evidences showing association of interleukin-1B polymorphisms with increased risk of gastric cancer in an Indian population. Biochem Biophys Res Commun 2009;387:456-60.
  • 42 Mbulaiteye SM, Hisada M, El-Omar EM. Helicobacter Pylori associated global gastric cancer burden. Front Biosci 2009;14:1490-504.
  • 43 Hamashima C, Shibuya D, Yamazaki H, Inoue K, Fukao A, Saito H, et al. The Japanese guidelines for gastric cancer screening. Jpn J Clin Oncol 2008;38:259-67.
  • 44 Shinkan Tokudome. Gastric Cancer. In, Tuncer AM (editor). Asian Pacific organization for cancer prevention: cancer report 2010. Ankara, Turkey: Asian Pacific organization for cancer prevention. Suvak, New hope in health foundation; 2010.
  • 45 Oishi Y, Kiyohara Y, Kubo M, Tanaka K, Tanizaki Y, Ninomiya T, et al. The serum pepsinogen test as a predictor of gastric cancer: The Hisayama study. Am J Epidemiol 2006;163:629-37.
  • 46 Zhou L, Yu H, Zheng S. The value of "occult blood bead" in detection of upper digestive tract disorders with bleeding. Zhonghua Zhong Liu Za Zhi 1999;21:48-50.
  • 47 Yeh JM, Kuntz KM, Ezzati M, Goldie SJ. Exploring the cost-effectiveness of Helicobacter pylori screening to prevent gastric cancer in China in anticipation of clinical trial results. Int J Cancer 2009;124:157-66.
  • 48 Ray G, Dey S, Pal S. Epidemiologic features of gastric cancer in a railway population in eastern India. J Assoc Physicians India 2007;55:248-9.