pISSN 1738-5520 eISSN 1738-5555
Indexed in PubMed, SCIE and Scopus
Open Access, Peer-reviewed, Monthly
    Korean Circ J. 2008 Jan;38(1):29-35. Korean.
    Published online Jan 31, 2008.
    https://doi.org/10.4070/kcj.2008.38.1.29
    Copyright © 2008 The Korean Society of Cardiology
    Original Article

    Distribution of Coronary Artery Calcification in an Asymptomatic Korean Population: Association with Risk Factors of Cardiovascular Disease and Metabolic Syndrome

    Donghee Kim, MD,1 Su-Yeon Choi, MD,1,2 Eue-Keun Choi, MD,2 Jung-Won Suh, MD,1,2 Whal Lee, MD,3 Young Sun Kim, MD,1 Dae Hyun Yoon, MD,1 Jin-Wook Chung, MD,2 and Byung-Hee Oh, MD2
      • 1Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea.
      • 2Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
      • 3Department of Radiology, Seoul National University College of Medicine, Seoul, Korea.
    • Correspondence: Su-Yeon Choi, MD, Seoul National University Hospital Healthcare System Gangnam Center, Department of Internal Medicine, Seoul National University College of Medicine, 39F Gangnam Finance Center, 737 Yeoksam-dong, Gangnam-gu, Seoul 135-984, Korea. Tel: 82-2-2112-5639, Fax: 82-2-2112-5635, Email: sychoi9@yahoo.co.kr
    Received September 21, 2007; Revised October 31, 2007; Accepted November 01, 2007.

    Abstract

    Background and Objectives

    Coronary artery calcification (CAC) has been used as surrogate marker for coronary atherosclerosis. We developed a set of age-and gender-stratified CAC distribution and risk factors for CAC in a population of asymptomatic Korean subjects.

    Subjects and Methods

    Between 2003 and 2007, 3,961 asymptomatic subjects without a history of ischemic heart disease (male 64%, mean age 56±10 years) were screened for CAC by the use of multi-detector computed tomography.

    Results

    The total CAC score was assigned to a percentile according to age and gender. The prevalence of CAC and mean CAC score increased with age [p<0.001 by analysis of variance (ANOVA)]. The prevalence of CAC (mean CAC score) was 36.2% (60.5±236.1) in males, and 17.0% (15.1±84.0) in females. The age-and sex-adjusted odds ratio for the presence of CAC for subjects with diabetes was 1.542 [95% confidence interval (CI) 1.252-1.899], for subjects with hypertension was 1.673 (95% CI 1.430-1.956), for subjects with metabolic syndrome was 1.727 (95% CI 1.461-2.042), and for subjects with abdominal obesity (abdominal obesity defined as a waist circumference ≥90 cm in males; ≥80 cm in females) was 1.445 (95% CI 1.222-1.709).

    Conclusion

    This study reports the distribution of CAC score by age and gender. It will serve as a reference standard for the clinical interpretation of CAC results in the asymptomatic Korean population.

    Keywords
    Coronary arteries; Pathologic calcification; Risk factors; Metabolic syndrome X

    Tables

    Table 1
    Baseline characteristics of study population

    Table 2
    Coronary artery calcium score in asymptomatic men (n=2,558) and women (n=1,403) within each age strata

    Table 3
    Multivariable-adjusted odds ratios for coronary artery calcium with metabolic risk factors

    Table 4
    Multivariable-adjusted odds ratios for coronary artery calcium with metabolic risk factors in asymptomatic men and women

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    MeSH Terms
    Biomarkers
    Calcinosis
    Cardiovascular Diseases
    Coronary Artery Disease
    Coronary Vessels
    Female
    Humans
    Hypertension
    Male
    Metabolic Syndrome X
    Myocardial Ischemia
    Obesity
    Obesity, Abdominal
    Odds Ratio
    Prevalence
    Risk Factors
    Waist Circumference
    Metrics
    Share
    Tables
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