A Clinical Study of Antihypertensive Effects of Doxazocin(Cardura®) in Essential Hypertension

Geong, Yeon Chae; Ku, Dae Hoe; Kim, Bag Su; Choi, Yong Seok; Seoung, In Hwan; Jeon, Eun Seok; Park, Chong Hun

doi:10.4070/kcj.1990.20.4.808

Korean Circ J. 1990 Dec;20(4):808-814. Korean.
Published online Dec 31, 1990.
https://doi.org/10.4070/kcj.1990.20.4.808

Original Article

A Clinical Study of Antihypertensive Effects of Doxazocin(Cardura®) in Essential Hypertension

Yeon Chae Geong, M.D., Dae Hoe Ku, M.D., Bag Su Kim, M.D., Yong Seok Choi, M.D., In Hwan Seoung, M.D., Eun Seok Jeon, M.D. and Chong Hun Park, M.D.

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Copyright and License

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The antihypertensive effect of Doxazocin were evaluated in 20 patients with essential hypertension. Two to eight mg of Doxazocin per day were administered continuously for two or eight weeks.

The results were as follows :

1) Doxazocin were effective in 18 out of 20 patients(90%) at the end of 8 weeks treatment.

2) The systolic blood pressure was signigicantly decreased(173±20mmHg VS 144±33mmHg, P±0.001), and the diastolic blood pressure was also decreased(110±10mmHg VS 93±19mmHg, P<0.01) after treatment.

3) Triglyceride showed a decreasing tendency but statistically significance was not observed. Total cholesteral, HDL-cholesterol, BUN, creatinine, and uric acid did not change significantly before and after treatment with Doxazocin.

4) The side effects were headache in one case and dizziness in to cases. These results suggest that Doxazocin is an effective antihypertensive agent and concerning lipid profile, further long term observation is needed.

Keywords

Doxazocin; Essential hypertension