Ketanserin in the Treatment of Essential Hypertension Over 55 Years Old

Lee, Bang Hun; Kim, Jeong Hyun; Lim, Heon Kil; Lee, Chung Kyun

doi:10.4070/kcj.1990.20.3.469

Korean Circ J. 1990 Sep;20(3):469-473. Korean.
Published online Sep 30, 1990.
https://doi.org/10.4070/kcj.1990.20.3.469

Original Article

Ketanserin in the Treatment of Essential Hypertension Over 55 Years Old

Bang Hun Lee, M.D., Jeong Hyun Kim, M.D., Heon Kil Lim, M.D. and Chung Kyun Lee, M.D.

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Copyright and License

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The effect of ketanserin, serotonin antagonist, among 19 korean patients over 55 years with essential hypertension was assessed in an open clinical trial for three months. patients were given Ketanserin 20mg bid with monthly follow-up visits. Mean values of systolic/diastolic blood pressures fell from 169±17/104±10mmHg to 155±14/94±9mmHg at 2 weeks(p<0.01) and to 147±10/87±6mmHg at end of treatment 12 weeks after(p<0.001).

There was no significant change in heart rate. Transient mild side effects were observed in 5 patients. We conclude that Ketanserin is an effective and safe drug for the treatment of elderly hypertensives.

Keywords

Ketanserin; Serotonin antagonist; Elderly hypertensive