Clinical Trial on the Antianginal Effect of Trapidil

Son, Joo Hyun; Shim, Jong Geol; Kim, Jeong Hyun; Lim, Heun Kil; Lee, Bang Hun; Lee, Chung Kyun

doi:10.4070/kcj.1988.18.2.251

Korean Circ J. 1988 Jun;18(2):251-255. Korean.
Published online Jun 30, 1988.
https://doi.org/10.4070/kcj.1988.18.2.251

Original Article

Clinical Trial on the Antianginal Effect of Trapidil

Joo Hyun Son, M.D., Jong Geol Shim, M.D., Jeong Hyun Kim, M.D., Heun Kil Lim, M.D., Bang Hun Lee, M.D. and Chung Kyun Lee, M.D.

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Copyright and License

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Antianginal effect of Trapidil was evaluated in 30 patients (18 male and 12 females) with angina rectoris.

The results were follows :

1) Antianginal effect of the drug were good in 18 cases (60%) and fair in 8 cases (37%), and there was no effect in 4 cases(13%).

2) Improvement in ECG changes was observed in 29%.

3) There were no significant change in CBC, RUA, LFT, serum electrolyte and lipid study before and after medication.

4) The adverse effects of trapidil were constipation, gastric cramp and dizziness, respectively one case. But they were not required discontinuing the medicetion.

On the basis of these results, Trapidol was evaluated to be promising antianginal drug.