Published online Sep 30, 1987.
https://doi.org/10.4070/kcj.1987.17.3.527
Clinical Trial on the Hypotensive Effect of Captopril
Abstract
The hypotensive effect and side reactions of captopril (combination with hydrochlorthiazide in some cases) were evaluated in 42 patients with essential hypertension.
The results were as follows:
1) Before medication and after 2, 4, 6, 8 and 10 weeks of medication, the over all average systolic & diastolic pressure were 178.2±42.6/111.3±21.1, 150.6±36.2/95.2±34.5, 140.3±31.4/93.6±24.3, 135.6±28.6/90.6±17.1, 130.9±20.5/87.9±16.4, 128.7±24.0/86.4±15.3mmHg respectively.
After 10 weeks of medication, marked or moderate degree of hypotensive effect was observed in 98% of all cases (systolic pressure), 93% of all cases (diastolic pressure)(P<0.001, P<0.001).
2) There was no significant changes in heart rates before and after treatment.
3) There was no side effects which required discontinuing the medication, decreasing the dose or other treatment for side effects.
