Antihypertensive Effect of Low-Dose Clonidine Monotherapy

Seo, Jung Don; Kim, Jong Sung; Lee, Chung Kyun; Ryoo, Un Ho; Park, Ock Kyu; Suh, Soon Kyu

doi:10.4070/kcj.1985.15.4.639

Korean Circ J. 1985 Dec;15(4):639-644. Korean.
Published online Dec 31, 1985.
https://doi.org/10.4070/kcj.1985.15.4.639

Original Article

Antihypertensive Effect of Low-Dose Clonidine Monotherapy

Jung Don Seo, M.D., Jong Sung Kim, M.D., Chung Kyun Lee, M.D., Un Ho Ryoo, M.D., Ock Kyu Park, M.D. and Soon Kyu Suh, M.D.

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This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The antihypertensive effect of clonidine was evaluated in 129 patients with essential hypertension of mild to moderate severity with a dosage of one tablet(0.075mg) a day for 71 patients of Group I and two tablets a day for 58 patients of Group II.

The results were as follows :

1) Of 71 patients of Group I, 34 patients(47.9%)showed good antihypertensive effect(greater than 15 mmHg drop in mean diastolic pressure) and 11 patients(15.5%) showed fair effect(10-14 mmHg drop in mean diastolic pressure).

2) Of 58 patients of Group II, 39 patients(67.2%) showed good effect and 7 patients(12.1%) showed fair effect.

3) The side effect observed was transient and tolerable dry mouth, which developed in 5.6% of Group I patients and 13.6% of Group II patients.