Published online Dec 31, 1984.
https://doi.org/10.4070/kcj.1984.14.2.373
Clinical Trial on the Hypotensive Effect of Buterazine
Abstract
The hypotensive effect and side reactions of Buterazine were evaluated in 21 patients with essential hypertension.
The results were as follows;
1) Before medication and after 2 and 4 weeks of medication, the over all average systolic and diastolic pressure were 188±23/112±7, 168±13/101±17, and 158±12/95±8mmHg, respectively. After 2 and 4 weeks of medication, the over all average systolic pressure decreased by 20 and 30mmHg(P<0.005, P<0.001), and the over all average diastolic pressure decreased by 11 and 17mmHg(P<0.025, P<0.001), respectively. In 69% of all cases, marked or moderate degree of hypotensive effect was observed.
2) There was no significant changes in heart rates before and after treatment.
3) In 84% of all cases, improvement of symptoms were observed.
4) There was no side effects which required discontinuing the treatment, except 2 cases which discontinued the medication.
