Open Access, Peer-reviewed
pISSN 1226-2102
eISSN 2005-8918
    J Korean Orthop Assoc. 2012 Jun;47(3):171-177. Korean.
    Published online Jun 26, 2012.
    https://doi.org/10.4055/jkoa.2012.47.3.171
    Copyright © 2012 by The Korean Orthopaedic Association
    Original Article

    The Effectiveness of C-Reactive Protein Surveillance as a Method to Monitor the Post-Operative Antibiotics Administration after Total Knee Replacement Arthroplasty

    Hyun-Jong Bong, M.D., Jun-Ki Moon, M.D., Jin-Kyu Lee, M.D. and Choong-Hyeok Choi, M.D.
      • Department of Orthopedic Surgery, College of Medicine, Hanyang University, Seoul, Korea.
    • Correspondence to: Choong-Hyeok Choi, M.D. Department of Orthopedic Surgery, Hanyang University Seoul Hospital, College of Medicine, Hanyang University, 222, Wangsimni-ro, Seongdong-gu, Seoul 133-792, Korea. TEL: +82-2-2290-8483 or 8485, FAX: +82-2-2299-3774, Email: chhchoi@hanyang.ac.kr
    Received August 09, 2011; Revised December 11, 2011; Accepted March 12, 2012.

    This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

    Abstract

    Purpose

    To evaluate the effectiveness of using C-reactive protein (CRP) surveillance as a method to monitor the effect of postoperative antibiotics for the prevention of early infection after total knee replacement arthroplasty (TKRA).

    Materials and Methods

    A prospective study was performed in 115 primary TKRAs. We examined the values of CRP of all cases on the 3rd, 5th, 7th, 10th and 14th days post-operatively. Some patients were administrated additional antibiotics under certain specific situations based on the pattern of CRP. The patients were divided into two groups: group I with planned period of administration and group II with administration longer than the planned period.

    Results

    No acute infection after TKRA due to CRP surveillance was observed. The mean duration of antibiotics administration was 5.9 days in all cases, 5 days in group I and 13.3 days in group II. Twelve cases (10.4%) were included in group II. The CRP was increased on the 5th and 10th days after operation in group II.

    Conclusion

    The surveillance of CRP was thought to be helpful in monitoring the effects of post-operative antibiotics and prevention of early infection after TKRA.

    Keywords
    knee; antibiotic prophylaxis; C-reactive protein (CRP); total knee replacement arthroplasty

    Figures

    Figure 1
    The mean values of CRP levels during post-operative periods in group I and group II. CRP, C-reactive protein; POD, post-operative day.

    Tables

    Table 1
    The Causes and Types of Over-Period Administration of Antibiotics after Total Knee Arthroplasty Replacement in Group II

    Table 2
    Diagnostic Values for the Surveillance of CRP Test in Post-Operative Morbidities

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    MeSH Terms
    Anti-Bacterial Agents
    Antibiotic Prophylaxis
    Arthroplasty
    Arthroplasty, Replacement, Knee
    C-Reactive Protein
    Humans
    Knee
    Organothiophosphorus Compounds
    Prospective Studies
    Metrics
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