Published online Apr 30, 2012.
https://doi.org/10.4055/jkoa.2012.47.2.86
The Prophylaxis of Venous Thromboembolism in Korean Patients with Total Knee Replacement Arthroplasty
Abstract
Purpose
To evaluate the effects and problems of venous thromboembolism (VTE) prophylaxis with a reduced dosage and administration period in Korean total knee arthroplasty (TKA) patients.
Materials and Methods
We analyzed 135 consecutive TKA patients with three different VTE prophylaxis regimens. Group dalteparin-aspirin (DA) injected dalteparin for the first 2 days, followed by taking aspirin for the next 5 days, Group aspirin (A) was on aspirin and Group dalteparin (D) on dalteparin 7 days postoperatively. We evaluated the incidence of VTE and safety among the 3 groups.
Results
Symptomatic deep vein thrombosis was detected in 4 cases (Group DA: 2, Group A: 1, Group D: 1). Pulmonary embolism (PE) was found in 1 case in each group with no fatal PE. Although no major bleeding complications were seen, minor bleeding incidents were detected in 14 cases (Group DA: 2, Group A: 1, Group D: 11), which was significant in Group D. No significant differences were observed in perioperative blood loss, effusion in the knee joint, thigh swelling or oozing on the wound area among the groups except thigh bruising, which developed more frequently in group D.
Conclusion
The reduced dosage and administration period of VTE prophylactic medicine combined with mechanical prophylaxis for Korean TKA patients showed no fatal PE, but some minor bleeding incidents frequently developed with 7 days of dalteparin injections. We need to adjust the dosage and duration of prophylactic medication deliberately for Korean TKA patients, considering prophylaxis effectiveness and bleeding complication risks.
Figure 1
A 75-year-old woman, who underwent total knee arthroplasty on her right knee, was diagnosed with deep vein thrombosis in the calf muscular tributary vein (arrow) by computed tomographic angiography.
Figure 2
A 74-year-old woman, who underwent total knee arthroplasty on her right knee, was diagnosed with thrombus at the popliteal area (A) and at the pulmonary vessel (B). These figures demonstrate deep vein thrombosis at the popliteal vein (arrow) and pulmonary embolism at right lower lobe basal segmental pulmonary artery (arrowhead) by computed tomographic angiography.
Table 1
Baseline Demographics and Clinical Characteristics of Population
Table 2
Incidence of Deep Vein Thrombosis, Pulmonary Embolism in Population after TKA
Table 3
Comparisons of Drainage Amount
Table 4
Hemorrhage according to Treatment Regimen
Table 5
Comparison of Clinical Outcomes
References
-
Virchow R. In: Cellular pathology as based upon physiological and pathologic histology: local formation of fibrin. London: Chruchil; 1860.
-
-
Seon JK, Song EK, Yoon TR, Park SJ, Bae BH, Cho SG. Comparison of functional results with navigation-assisted minimally invasive and conventional techniques in bilateral total knee arthroplasty. Comput Aided Surg 2007;12:189–193.
-
-
Pandit H, Aslam N, Pirpiris M, Jinnah R. Total knee arthroplasty: the future. J Surg Orthop Adv 2006;15:79–85.
-
-
Nadler S, Hidalgo J, Bloch T. Prediction of blood volume in normal human adults. Surgery 1962;51:224–232.
-
-
Kane D, Balint PV, Sturrock RD. Ultrasonography is superior to clinical examination in the detection and localization of knee joint effusion in rheumatoid arthritis. J Rheumatol 2003;30:966–971.
-
-
Warwick D, Harrison J, Glew D, Mitchelmore A, Peters TJ, Donovan J. Comparison of the use of a foot pump with the use of low-molecular-weight heparin for the prevention of deep-vein thrombosis after total hip replacement. A prospective, randomized trial. J Bone Joint Surg Am 1998;80:1158–1166.
-
-
Haas SB, Barrack RL, Westrich G, Lachiewicz PF. Venous thromboembolic disease after total hip and knee arthroplasty. J Bone Joint Surg Am 2008;90:2764–2780.
-
-
American academy of orthopaedic surgeons clinical guideline on prevention of symptomatic pulmonary embolism in patients undergoing total hip or knee arthroplasty. American Academy of Orthopaedic Surgeons Board of Directors. 2007 May [accessed 2009 Sep 9].Available from: www.aaos.org/research/guidelines/PE_
guideline.pdf.
-
-
Johanson NA, Lachiewicz PF, Lieberman JR, et al. Prevention of symptomatic pulmonary embolism in patients undergoing total hip or knee arthroplasty. J Am Acad Orthop Surg 2009;17:183–196.
-
-
Turpie AG, Bauer KA, Eriksson BI, Lassen MR. PENTATHALON 2000 Study Steering Committee. Postoperative fondaparinux versus postoperative enoxaparin for prevention of venous thromboembolism after elective hip-replacement surgery: a randomised double-blind trial. Lancet 2002;359:1721–1726.
-
-
Lassen MR, Bauer KA, Eriksson BI, Turpie AG. European Pentasaccharide Elective Surgery Study (EPHESUS) Steering Committee. Postoperative fondaparinux versus preoperative enoxaparin for prevention of venous thromboembolism in elective hip-replacement surgery: a randomised double-blind comparison. Lancet 2002;359:1715–1720.
-
-
Kim HJ. Epidemiology of VTE in orthopaedic patients. In: Yoo MC, Kim HJ, Choi CH, editors. Venous thromboembolism in orthopaedics. Seoul: BMM Korea; 2010. pp. 15-46.
-
-
Wang CJ, Wang JW, Chen LM, Chen HS, Yang BY, Cheng SM. Deep vein thrombosis after total knee arthroplasty. J Formos Med Assoc 2000;99:848–853.
-
-
Sikorski JM, Hampson WG, Staddon GE. The natural history and aetiology of deep vein thrombosis after total hip replacement. J Bone Joint Surg Br 1981;63:171–177.
-
-
The Danish Enoxaparin Study Group. Low-molecular-weight heparin (enoxaparin) vs dextran 70. The prevention of postoperative deep vein thrombosis after total hip replacement. Arch Intern Med 1991;151:1621–1624.
-