Open Access, Peer-reviewed
pISSN 1226-2102
eISSN 2005-8918
    J Korean Orthop Assoc. 2008 Apr;43(2):247-251. Korean.
    Published online Apr 30, 2008.
    https://doi.org/10.4055/jkoa.2008.43.2.247
    Copyright © 2008 The Korean Orthopaedic Association
    Case Report

    Aberrant Chromosomal Alterations in Bizarre Parosteal Osteochondromatous Proliferation (Nora's Lesion) of Hand - A Case Report -

    Kap-Jung Kim, M.D., Ha Yong Kim, M.D., Dae Suk Yang, M.D., Won-Sik Choy, M.D. and Chun Wha Ihm, M.D.*
      • Department of Orthopaedic Surgery, Eulji University College of Medicine, Daejeon, Korea.
      • *Department of Laboratory Medicine, Eulji University College of Medicine, Daejeon, Korea.
    • Address reprint requests to Kap-Jung Kim, M.D. Department of Orthopaedic Surgery, Eulji University College of Medicine, 1306, Dunsan-dong, Seo-gu, Daejeon 302-102, Korea. Tel: +82.42-611-3279, Fax: +82.42-259-1289, Email: oskkj@eulji.ac.kr

    Abstract

    Bizarre parosteal osteochondromatous proliferation is a disease similar to an osteochondroma that usually involves the metatarsal, metacarpal, proximal and middle phalanx. The symptoms are normally caused by the bone mass, the condition has a benign clinical course but recurrence is common. Recently, it was reported that there is a translocation between chromosome 1 and 17. We report a case of BPOP in the middle phalanx of hand with translocations and duplication in cytogenetic karyotyping with a review of relevant literature.

    Keywords
    Hand; Bizarre parosteal osteochondromatous proliferation; Cytogenetic karyotyping

    Figures

    Fig. 1
    Photographs showing a dorsoulnar bony mass located in the middle phalanx of the 4th finger.

    Fig. 2
    Preoperative radiographs showing a 7×7 mm sized exostotic mass on the dorsoulnar aspect middle phalanx of the 4th finger. The protruding bony mass does not connect with the medullary cavity of middle phalanx.

    Fig. 3
    Computed tomography scans showing an irregular and calcified mass of the middle phalanx.

    Fig. 4
    Intraoperative photograph showing a whitish and irregular calcified mass.

    Fig. 5
    Photomicrograph showing a bizarre chondrocyte, osteoid and spindle cells that favor bizarre parosteal osteochondromatous proliferation (BPOP).

    Fig. 6
    Cytogenetic karyotyping showing t(3;17)(p21;p13), t(7;15)(q32;q15) and dup(15)(q15;q22).

    Fig. 7
    Postoperative 12 months radiographs showing no evidence of local recurrence.

    References

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      1. Nilsson M, Domanski HA, Mertens F, Mandahl N. Molecular cytogenetic characterization of recurrent translocation breakpoints in bizarre parosteal osteochondromatous proliferation (Nora's lesion). Hum Pathol 2004;35:1063–1069.
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    MeSH Terms
    Chromosomes, Human, Pair 1
    Cytogenetics
    Hand
    Karyotyping
    Metatarsal Bones
    Osteochondroma
    Recurrence
    Metrics
    Share
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