Published online Aug 31, 2007.
https://doi.org/10.4055/jkoa.2007.42.4.490
The Expression of the Adhesion Molecules on Interfacial Membrane from the Aseptically Loosened Failed Femoral Stems in Revisional Hip Arthroplasty
Abstract
Purpose
To clarify the relationship between aseptic loosening of hip arthroplasty and adhesion molecules on interfacial membrane from revisional hip arthroplasty.
Materials and Methods
We studied 26 revisional total hip arthroplasties between May 2004 and July 2006, and 15 synovial tissues from hip fractures were selected as the control group. We analyzed the degree of femoral osteolysis by Paprosky's classification. We examined the expression of soluble endothelial leukocyte adhesion molecule-1 (E-selectin), vascular adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) by immunohistochemical staining technique. We compared and analyzed radiologic evaluation and expression of adhesion molecules.
Results
Expression of E-selectin was observed in 100%, VCAM-1 in 42.3% and ICAM-1 in 34.6%. Expression of adhesion molecules were increased compared to the control group (p<0.05). The higher the expression of E-selectin, the higher the degree of osteolysis (p=0.023).
Conclusion
These results showed that adhesion molecules are involved in aseptic loosening of hip arthroplasties, and we proposed that E-selectin may strongly engage in the cascade of aseptic loosening in hip arthroplasty.
Fig. 1
A microscopic image demonstrating vessels stained with antibody to E-selectin (arrow). (A) Negative for staining. (B) 1st grade of intensity and 1st grade of proportion. (C) 1st grade of intensity and 2nd grade of proportion (×100).
Table 1
Detailed Clinical Data of the Revision Patients
Table 2
Histologic Findings of Revision Patients (H&E Stain)
Table 3
Comparison between Cemented Cases and Uncemented Cases in Patient Group
Table 4
Comparison between Patients and Control Group in Stainability of Adhesion Molecules
Table 5
Paprosky's Classification of the Patient Group
Table 6
Correlation between Modified Paprosky Classification and Stainability of Adhesion Molecule
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