pISSN 1738-6756   eISSN 2092-9900
Open Access, Peer-reviewed
    J Breast Cancer. 2006 Sep;9(3):241-248. Korean.
    Published online Sep 30, 2006.
    https://doi.org/10.4048/jbc.2006.9.3.241
    Copyright © 2006 Korean Breast Cancer Society
    Original Article

    Surgical Treatment of Locoregional Recurrence in Breast Cancer

    Jeoung Kyeung Kim, Byung Ho Son, Beom Seok Kwak, Ui Kang Hwang,1 Hee Jeong Kim, Jung Sun Lee, Soo Jung Hong, Min Sung Jung, Seung Do Ahn,2 and Sei Hyun Ahn
      • Department of Surgery, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Korea.
      • 1Department of Surgery, Hanmaeum hospital, sacheon, Korea.
      • 2Department of Radiation oncology, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Korea.
    • Corresponding author (Email: ahnsh@amc.seoul.kr )
    Received January 25, 2006; Accepted May 29, 2006.

    Abstract

    Purpose

    The locoregional recurrence (LRR) in breast cancer, without distant metastasis has traditionally been regarded as a predictor of subsequent distant metastasis. This study was designed to attain the survival rate, disease progress in patients with a LRR only and to approve a locoregional treatment able to increase the survival in specific locoregional recurrent breast cancer.

    Methods

    The records of 223 patients with LRR, after initial treatment at the Asan Medical Center, between 1989 and 2003, were retrospectively reviewed. The patients were classified into the LRR only and simultaneous distant metastasis groups with the LRR group subdivided into the operable and inoperable groups. The data were analyzed using SPSS 11.0.

    Results

    There were 152 and 71 patients in the LRR only and simultaneous distant metastasis groups respectively: 105 patients in the LRR only group were operable cases. The 5-year survival rate of LRR was 42.5%, but this was 50.1% in the LRR only group. The 5-year survival rates following a recurrence in the operable and inoperable groups were 66.2% and 21.1%. On multivariate analysis, age at the primary surgery, tumor size, hormone receptor status and DFI were independent prognostic factors for survival. The operable group indicated less tumor size at the primary surgery, less lymph node metastasis and more chest wall or axillary lymph node recurrences, compared to the inoperable group.

    Conclusion

    In some of the LRR only cases, the survival rate was relatively good, especially in the operable group. Age at the primary surgery, tumor size, hormone receptor status and DFI were independent prognostic factors for survival. Surgical treatment could be resulted in good responses to the LRR patients with early stage or chest wall or axillary recurrences.

    Keywords
    Locoregional recurrence; Breast cancer; Survival; Surgical treatment

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    MeSH Terms
    Breast Neoplasms*
    Breast*
    Chungcheongnam-do
    Humans
    Lymph Nodes
    Multivariate Analysis
    Neoplasm Metastasis
    Recurrence*
    Retrospective Studies
    Survival Rate
    Thoracic Wall
    Metrics
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