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Kim, Koh, Suh, Chung, Kim, Suh, and Kwon: The Usefulness and Safety of Natural Stent in a Canine Model of Tracheal Stenosis
Original Article
Clinical Trial

Tuberculosis and Respiratory Diseases 2002; 53(4): 431-438.

Published online: 31 October 2002

DOI: https://doi.org/10.4046/trd.2002.53.4.431

The Usefulness and Safety of Natural Stent in a Canine Model of Tracheal Stenosis

Ho Joong Kim, M.D., Won Jung Koh, M.D., Gee Young Suh, M.D., Man Pyo Chung, M.D., Jhin Gook Kim, M.D.*, Soo Won Suh, Ph.D., O Jung Kwon, M.D.**

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

*Department of Medicine, Department of Thoracic Surgery, Engineering, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

**Department of Medical Engineering, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Address for correspondence (ojkwon@smc.samsung.co.kr)

Copyright©2002. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved.

Abstract

Background

In order to investigate the usefulness and safety of Natural Stent, we performed this study in a canine model of tracheal stenosis induced using Nd-YAG laser.

Methods

After tracheal stenosis was induced in 12 Mongrel dogs using Nd-YAG laser, either Dumon (n=6) or Natural (n=6) stent was inserted into the trachea. To assess the degree of stent migration and mucostasis, bronchoscopy was performed every week for 4 weeks, after which all stents were removed. One week after stent removal, tracheal stenosis was evaluated by bronchoscopy.

Results

The degree of stent migration was not different between the dogs with Dumon stent (3.0±0.8) and those with Natural (2.0±1.0), nor was the degree of mucostasis, at Dumon (1.7±0.5) and Natural Stent (1.5±0.6), respectively. One week after stent removal, the degree of tracheal stenosis was not different between the Dumon (1.5±0.5) and the Natural group (1.0±0.4). In addition, there was no death and the degree of tracheal stenosis remained always within the safe limit (less than 2.0) in all animals.

Conclusions

In a canine model of tracheal stenosis induced using Nd-YAG laser, the usefulness and safety of Natural Stent were similar to those of Dumon Stent. A clinical trial is necessary to document the usefulness and safety of Natural Stent in patients with tracheal stenosis.

Keywords: Animal, Airway, Bronchoscopy

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