First case of vaccine derived poliovirus isolated from a patient with a primary immune deficiency in Sri Lanka

Persons with primary immune deficiency disorders (PID) exposed to oral polio vaccine (OPV)) are at increased risk of vaccine-associated paralytic poliomyelitis (VAPP)  and prolonged excretion of vaccine-derived polioviruses (VDPVs)

VDPVs are identified by a genetic divergence of at least 1%, or with Poliovirus 2, at least 0.6% in the VP1 region from the parent Sabin strain. A potential source of VDPV is a person with PID who excretes vaccine-derived polioviruses (iVDPVs).  These viruses may occasionally cause paralytic disease in the patient with PID, but has not been reported to have caused outbreaks of paralysis in immunologically normal people

We report the first isolate of iVDPV in Sri Lanka from a child with severe combined immune deficiency (SCID).

DOI: http://dx.doi.org/10.4038/sljid.v4i2.6672

Sri Lankan Journal of Infectious Diseases 2014; Vol.4(2):115-118