Abstract
Disorders in human Genetics impact their reproductive potential in several ways such as fertility, retaining fertility and fertility treatment outcomes. However, alterations in genes might be harmless or can bring about detrimental outcomes. Understanding the impact of genetics on reproduction is essential to have better fertility outcomes. An individualized assessment of a couple to identify the underlying aetiology related to genetic problems along with genetic testing is considered the first step of the solution. Moreover, assisted reproductive technologies (ART) are a possible fertility treatment option to address feasible genetic problems even before the establishment of pregnancy. A pre-ART assessment of a couple with potential genetic problems can be carried out with expanded carrier screening and genetic analysis of the gametes and embryo during the ART procedure to detect abnormalities and select a healthy embryo are play an indispensable role to overcome this puzzle.