Hydroxyapatite/Polyvinyl Alcohol Composite Hydrogels for Bone and Cartilage Tissue Engineering

Anna Timofejeva; Dagnija Loca

doi:10.4028/www.scientific.net/KEM.762.54

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HomeKey Engineering MaterialsKey Engineering Materials Vol. 762Hydroxyapatite/Polyvinyl Alcohol Composite...

Hydroxyapatite/Polyvinyl Alcohol Composite Hydrogels for Bone and Cartilage Tissue Engineering

Abstract:

Composite hydrogels on the basis of hydroxyapatite (HAp) and polyvinyl alcohol (PVA) has been proposed as a promising materials for bone and cartilage tissue engineering. HAp/PVA composite hydrogels with phase ratio 50:50wt% and 70:30wt% were obtained via in situ wet chemical precipitation technique in combination with the freeze-thawing approach. The XRD studies of sintered products revealed that HAp/PVA composite hydrogels synthesized from PVA with degree of hydrolysis (DH) 98% and molecular weights (MW) 25 kDa and 78 kDa are more suitable for biomedical purposes due to the formation of stoichiometric HAp. Swelling studies indicated that HAp/PVA 50:50 (78 kDa, 88% and 98%) hydrogels after 24h of immersion swell ~4.25-6.5 times less than identical samples with phase composition of 70:30wt%, which is accounted to different number of intermolecular hydrogen bonds formed. After 16 subsequent freeze-thawing cycles (FTC), HAp/PVA 50:50 (78 kDa, 88% and 98%) hydrogels contain ~1.2 times higher content of crosslinked PVA than HAp/PVA 70:30 (78 kDa, 88% and 98%) hydrogel samples.

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Periodical:

Key Engineering Materials (Volume 762)

Pages:

54-58

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.762.54

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Online since:

February 2018

Authors:

Anna Timofejeva*, Dagnija Loca

Keywords:

Bone, Cartilage, Hydrogels, Hydroxyapatite, In Situ, Polyvinyl Alcohol, Tissue Engineering

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* - Corresponding Author

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