Use New PDLLA/PRGD Nerve Conduits for Promoting Peripheral Nerve Regeneration

Tong Qiu

doi:10.4028/www.scientific.net/AMR.884-885.553

Paper Titles

Study on Hydrolysis Conditions of Lactobacillus bulgaricus on Casein Sodium by Method of Response Surface and the Antioxidant Activity of Hydrolysates
p.535

The Application of PCR-DGGE Technique in Sheep Intestinal Microbial Diversity Research
p.540

The Effects of Floating Granulosa Cells Density on the Developmental Competence of Bovine Oocytes: A Study Using the Well-in-Well Culture System
p.544

Two New Natural Products from the Roots of Raphanus sativus L.
p.548

Use New PDLLA/PRGD Nerve Conduits for Promoting Peripheral Nerve Regeneration
p.553

Using 2D-PAGE and Mass Spectrometry (LC-MS/MS) for Embryo Proteins Analysis in Antheraea pernyi
p.556

Comparison of Chemical Properties and Ni Release of Stainless Steel and Nickel Titanium Wires
p.560

Determination of Picogram Levels of Levodopa in Pharmaceutical Preparations and Biofluids by Flow-Injection Chemiluminescence
p.566

Fast Testing Methods on the Performance of Laser Confocal Micro-Raman Spectroscopy System for Cell Analysis
p.570

HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 884-885Use New PDLLA/PRGD Nerve Conduits for Promoting...

Use New PDLLA/PRGD Nerve Conduits for Promoting Peripheral Nerve Regeneration

Abstract:

Nerve conduits provide a promising strategy for peripheral nerve injury repair. Additional factors in nerve conduits such as cell adhesion molecules help to provide a more conducive microenvironment for nerve regeneration. In the present study, poly lactic acid (PDLLA) was modified by grafting Gly-Arg-Gly-Asp-Gly (RGD peptide) for fabricating new PDLLA/PRGD nerve conduits to promote nerve regeneration and functional recovery. In vivo, RGD addition improve the recovery efficiency of the transected nerve, that is, the sciatic function index (SFI) value of the PDLLA/PRGD group was significantly higher than those of group PDLLA. The regenerated nerves in PDLLA/PRGD group were more mature with significant elevations in both the cytoskeletal proteins expressions and the nerve growth factors expressions. Taken together, RGD peptide is one of the good candidates to enhance the biocompatibility of the biomaterials and facilitate the peripheral nerve regeneration.