Characterization of Zinc Oxide Nanoparticles and their Inhibitory Effect on Human Lens Epithelial Cells under UVB Irradiation

Da Dong Guo; Hong Ying Tang; Hong Sheng Bi

doi:10.4028/www.scientific.net/AMR.788.61

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 788Characterization of Zinc Oxide Nanoparticles and...

Characterization of Zinc Oxide Nanoparticles and their Inhibitory Effect on Human Lens Epithelial Cells under UVB Irradiation

Abstract:

Posterior capsular opacification is the most frequent complication after cataract surgery, which is induced by the proliferation, differentiation and migration of lens epithelial cells. Inhibiting the proliferation of human lens epithelial cells could reduce the occurrence of posterior capsular opacification. To explore the possible potential of ZnO nanoparticles in treating posterior capsular opacification, we investigated the effect of ZnO nanoparticles on the human lens epithelial cell proliferation in the presence and absence of ultraviolet B (UVB) irradiation via 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay. The results indicate that ZnO nanoparticles could apparently inhibit the proliferation of human lens epithelial cells in a dose-dependent manner, and UVB irradiation can further enhance this inhibitory role for the human lens epithelial cell proliferation, indicating the great potential of ZnO nanoparticles in treating posterior capsular opacification in clinical application.

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Periodical:

Advanced Materials Research (Volume 788)

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61-64

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.788.61

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Online since:

September 2013

Authors:

Da Dong Guo, Hong Ying Tang, Hong Sheng Bi

Keywords:

Irradiation, Lens Epithelial Cell, MTS Assay, Nanoparticle, Ultra Violet B, Zinc Oxide (ZnO)

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