Study on Key Parameters of Ft-IMS Based on Simulation

Article Preview

Abstract:

Ion Mobility Spectrometer (IMS) is an effective instrument for detecting narcotics and explosives. Signal average IMS (SA-IMS) is used widely because it is relatively convenient to build. SA-IMS is low efficient in utilization of sample ions (1%), while FT-IMS is relatively high (25%). However, detailed discussions of several important parameters, such as frequency sweeping range, frequency sweeping intervals and gating function distortion, have not been made in previous studies. In this article, we build a numerical simulation model of FT-IMS, with which we appraised these parameters respectively. Main job of this article is done with MATLAB. We also propose several guidelines in building FT-IMS.

You might also be interested in these eBooks

Info:

Periodical:

Pages:

388-394

Citation:

Online since:

June 2014

Export:

Price:

* - Corresponding Author

[1] H. Hill Jr., W.F. Siems : Ion mobility spectrometry, Anal. Chem. (1990), 1201A-1209A.

DOI: 10.1021/ac00222a716

Google Scholar

[2] H. Borsdorf G.A. Eiceman: Ion Mobility Spectrometry: Priciples and Applications, Applied Spectroscopy Reviews(2006), 323-375.

DOI: 10.1080/05704920600663469

Google Scholar

[3] G.A. Eiceman,Z. Karpas: Ion Mobility Spectrometry, CRC Press(2005), Chapter 4.

Google Scholar

[4] M. Teepe J.I. Baumbach et al: Miniaturized ion mobility spectrometer, IJIMS 4(2001)1, 60-64.

Google Scholar

[5] M.E. Belov M.A. Buschbach D.C. Prior,K. Tang R.D. Smith: Multiplexed Ion Mobility Spectrometry-Orthogonal Time-of-Flight Mass Spectrometry, Anal. Chem. (2007), 2451-2462.

DOI: 10.1021/ac0617316

Google Scholar

[6] K.B. Pfeifer, S.B. Rohde: Signal-to-Noise and Resolution Enhancement in Ion Mobility Spectrometry Using Correlaton Gating Technique: Barker Codes, Sensor(2007), 1130-1137.

DOI: 10.1109/jsen.2007.897961

Google Scholar

[7] F. Knorr R.E.: Fourier Transform Ion Mobility Spectrometry, Anal. Chem. (1985), 402-406.

Google Scholar

[8] H.L. Robert, F.S. William H.H. Herbert: Apodization Functions in Fourier Transform Ion Mobility, Anal. Chem. (1992), 171-177.

Google Scholar

[9] B.C. Bohrer S.I. Merenbloom S.L. Koeniger A.E. Hilderbrand D.E. Clemmer: Biomolecule Analysis by Ion Mobility Spectrometry, Anal. Chem. (2008), 293-327.

DOI: 10.1146/annurev.anchem.1.031207.113001

Google Scholar

[10] J. Laakia,A. Adamov,M. Jussila C.S. Pedersen A.A. Sysoev.T. Kotiaho: Separation of Different Ion Structures in Atmospheric Pressure Photoionization-Ion Mobility Spectrometry-Mass Spectrometry (APPI-IMS-MS),J. Am. Soc. Mass Spectrom(2010).

DOI: 10.1016/j.jasms.2010.04.018

Google Scholar

[11] R. Dietiker F.D. Lena: Fourier Transform Ion Mobilty Measurement,J. AM. CHEM. SOC. (2007), 2796-2802.

Google Scholar

[12] P. Dugourd R.R. Hudgins D.E. Clemmer M.F. Jarrold: High-resolution ion mobility measurements, Sci. Instrum. (1997), 1123-1129.

DOI: 10.1063/1.1147873

Google Scholar

[13] E.T. Edward: External Second Gate Fourier Transform Ion Mobility Spectrometry: ParametetricOptimization for Detection of Weapons of Mass Destruction, Sensors (2004), 1-13.

DOI: 10.3390/s40100001

Google Scholar