Effects of Sufentanil Postconditioning on Myocardial Ischemia-Reperfusion Injury in Rats In Vivo

Da Peng Gao; Guo Qing Zhao; Jia Wang; Ming Gao

doi:10.4028/www.scientific.net/AMM.464.37

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HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vol. 464Effects of Sufentanil Postconditioning on...

Effects of Sufentanil Postconditioning on Myocardial Ischemia-Reperfusion Injury in Rats In Vivo

Abstract:

Objective.To investigates the effects of sufentanil post conditioning on Myocardial ischemia reperfusion injury in rats in vivo. Methods. To randomly divide 40 male SD rats equally into 4 groups, including Sham group, ischemia-reperfusion group (Group I/R ), ischemic post conditioning group (Group IPO) and sufentanil post conditioning group (Group SUF). The left anterior descending coronary arterys (LAD) of rats in 4 groups are ligated for 30 minutes and are re-perfused for 120 mins. To measure the myocardial infarction size (IS/AAR%) with double-staining with Even's blue and triphenyltetrazolium chloride, to calculate the concentration of cTnI, and to observe the HE staining and the expression of Bcl-2 and Bax. Result. Comparing with Group 1/R, the myocardial infarction size (IS/AAR%), and the concentration of cTnI in Group IPO and SUF all reduced significantly. Comparing with Group 1/R, cell morphological observation shows less change in pathology. And the expression of Bcl-2 increases and expression of Bax decreases in Group IPO and SUF than that in Group 1/R. Conclusion. Sufentanil post conditioning has protective effects on myocardial ischemia-reperfusion injury in rats in vivo.

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Periodical:

Applied Mechanics and Materials (Volume 464)

Pages:

37-40

DOI:

https://doi.org/10.4028/www.scientific.net/AMM.464.37

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Online since:

November 2013

Authors:

Da Peng Gao, Guo Qing Zhao, Jia Wang, Ming Gao*

Keywords:

Ischemic Post Conditioning, Myocardial Ischemia-Reperfusion Injury, Sufentanil

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* - Corresponding Author

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