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HomeMaterials Science ForumMaterials Science Forum Vol. 1061Copper-Catalyzed-Multicomponent Reaction towards...

Copper-Catalyzed-Multicomponent Reaction towards the Synthesis of γ-Hydroxybutyrolactams

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Abstract:

Copper-catalyzed-multicomponent reaction has been applied to prepare several examples γ-hydroxybutyrolactams. The synthesis of γ-hydroxybutyrolactams occurred via cascade sequence comprising Sonogashira coupling, heterocyclization and nucleophilic addition reactions. The reaction involved the starting materials of (Z)-3-iodobutenoic acid, terminal alkynes and butylamine. The results showed that electronic effect of terminal alkynes played important role in synthesis of γ-hydroxybutyrolactams. The multicomponent reaction allowed us to obtain the desired products and to create multiple bonds in one-pot fashion.

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Materials and Chemical Technologies

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Periodical:

Materials Science Forum (Volume 1061)

Pages:

151-156

DOI:

https://doi.org/10.4028/p-yux0t7

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Online since:

May 2022

Authors:

Muhammad Idham Darussalam Mardjan*, Jean Luc Parrain, Laurent Commeiras

Keywords:

Copper Catalysis, Heterocyclization, Multicomponent Reaction, Nucleophilic Addition, Sonogashira Coupling, γ-Butyrolactams

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