Increased Osteoblast Proliferation on Hydroxyapatite Thin Coatings Produced by Right Angle Magnetron Sputtering

Zhen Hong; Alexandre Mello; Tomohiko Yoshida; Lan Luan; Paula H. Stern; Antonella M. Rossi; Donald E. Ellis; J.B. Ketterson

doi:10.4028/www.scientific.net/KEM.361-363.215

Paper Titles

Mg-Free Precursors for the Synthesis of Pure Phase Si-Doped α-Ca₃(PO4)₂
p.199

Effect of Mg²⁺ Addition during HA Nanoparticles Synthesis Using Ultrasonic Irradiation
p.203

Synthesis and Stability of Potassium/Carbonate Co-Substituted Hydroxyapatites
p.207

Preparation of Porous Synthetic Nanostructured HA Scaffold
p.211

Increased Osteoblast Proliferation on Hydroxyapatite Thin Coatings Produced by Right Angle Magnetron Sputtering
p.215

Crystallographic Changes of Bioceramic Composition of Cadever Bone on Heat Treatments
p.219

In Vitro Behavior of Fiber Bundles and Particles of Bioactive Glasses
p.225

In Vitro Assessment of New Niobium Phosphate Glasses and Glass Ceramics
p.229

Glass-Ceramic Scaffolds and Shock Waves Effect on Cells Migration
p.233

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Increased Osteoblast Proliferation on Hydroxyapatite Thin Coatings Produced by Right Angle Magnetron Sputtering

Abstract:

Crystalline hydroxyapatite thin coatings have been prepared using a novel opposing RF magnetron sputtering approach at room temperature. X-ray diffraction (XRD) analysis shows that all the principal peaks are attributable to HA, and the as-deposited HA coatings are made up of crystallites in the size range of 50-100nm. Fourier transform infrared spectroscopy (FTIR) studies reveal the existence of phosphate, carbonate and hydroxyl groups, suggesting that HA coatings are highly crystalline. To study the biocompatibility of these coatings, murine osteoblast cells were seeded onto various substrates. Cell density counts using fluorescence microscopy show that the best osteoblast proliferation is achieved on an HA RAMS-coated titanium substrate. These experiments demonstrate that RAMS is a promising coating technique for biomedical applications.