Novel antimicrobial denture adhesive containing S-PRG filler

Keita HATANO; Masanao INOKOSHI; Muneaki TAMURA; Motohiro UO; Makoto SHIMIZUBATA; Watcharapong TONPRASONG; Takahiro WADA; Rena TAKAHASHI; Kenichi IMAI; Shunsuke MINAKUCHI

doi:10.4012/dmj.2020-443

Original Paper

Novel antimicrobial denture adhesive containing S-PRG filler

Keita HATANO, Masanao INOKOSHI, Muneaki TAMURA, Motohiro UO, Makoto SHIMIZUBATA, Watcharapong TONPRASONG, Takahiro WADA, Rena TAKAHASHI, Kenichi IMAI, Shunsuke MINAKUCHI

Author information

Keita HATANO
Department of Gerodontology and Oral Rehabilitation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
Masanao INOKOSHI
Department of Gerodontology and Oral Rehabilitation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
Muneaki TAMURA
Department of Microbiology, Nihon University School of Dentistry
Motohiro UO
Department of Advanced Biomaterials, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
Makoto SHIMIZUBATA
Department of Gerodontology and Oral Rehabilitation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
Watcharapong TONPRASONG
Department of Gerodontology and Oral Rehabilitation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
Takahiro WADA
Department of Advanced Biomaterials, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
Rena TAKAHASHI
Department of Cariology and Operative Dentistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
Kenichi IMAI
Department of Microbiology, Nihon University School of Dentistry
Shunsuke MINAKUCHI
Department of Gerodontology and Oral Rehabilitation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University

Keywords: Surface pre-reacted glass-ionomer (S-PRG) filler, Denture adhesive, Antimicrobial effect, Candida albicans

JOURNAL FREE ACCESS

2021 Volume 40 Issue 6 Pages 1365-1372

DOI https://doi.org/10.4012/dmj.2020-443

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Abstract

The antimicrobial effects of denture adhesives containing novel surface pre-reacted glass-ionomer (S-PRG) fillers were assessed. We prepared denture adhesives containing S-PRG (particle sizes: 1 and 3 µm; quantities: 5, 7.5, and 10 wt%). We evaluated acid buffering capacity, ion release, and antimicrobial effects of denture adhesives with and without S-PRG. Significantly higher pH changes were observed in 1 µm S-PRG adhesives than in 3 µm S-PRG adhesives. Adhesives containing 7.5 and 10 wt% S-PRG exhibited significantly higher ion release than adhesives with 5 wt% S-PRG. The 1µm–10wt% S-PRG denture adhesive exhibited significantly lower colony-forming units on the denture adhesive contact surface than in the control group; additionally, it exhibited excellent acid buffering capacity, ion release properties, and antimicrobial effect against C. albicans, C. glabrata, S. mutans, and A. naeslundii. Longer contact periods resulted in significantly lower adhesion of Candida albicans to the denture base resin treated with denture adhesive.

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