Abstract:AIM: To investigate the expression and relationship of S-phase kinase-associated protein 2(Skp2)and p27 in mucosa-associated lymphoid tissue(MALT)lymphoma of ocular adnexal.
METHODS:The expression of Skp2, p27 were detected on resected specimens from patients suffering from MALT lymphoma and lymphadenosis of ocular adnexal in Ophthalmology Department, Affiliated Hospital of Medical College Qingdao University from 1995 to 2011 by immunohistochemical analysis.
RESULTS: The expression of Skp2 in MALT lymphoma was higher than that in lymphadenosis(P<0.05). The expression of p27 in MALT lymphoma was lower than that in lymphadenosis(P<0.05). The expression of Skp2 and p27 do not related with the Ann Arbor clinical stage. There was a negative correlation between p27 and Skp2 in MALT lymphoma(r=-0.129,χ2=15.39, P<0.05).
CONCLUSION: Comprehensive analysis of the expression of p27 and Skp2 protein may have certain guiding significance on the prognosis evaluation of the disease. The expression of two substances may correlate with each other.
