AIM: To observe effects of four effective components of Qing Guang An on inoblast and typeⅠcollagen of scarring tissue of filtration canal after glaucoma surgery, and discuss their effect and function mechanism on preventing its formation.

METHODS: Four effective components of Qing Guang An were used in rabbit eyes after glaucoma surgery(Group D.E.F.G), with the blank group(A), model group(B), MMC group comparison(C). Effects of four effective components of Qing Guang An on inoblast and typeⅠcollagen of scarring tissue of filtration canal after glaucoma surgery were observed.

RESULTS: After surgery, MMC group(C), effective component 2(E)groups of intraocular pressure rose slowly. At the fourth week, intraocular pressure remained minimum. The compare of these two groups of intraocular pressure and those of group A, B, D, F, G had significance on statistics. Comparing with the number of inoblast of each group, except group D and E, which result was P>0.05 and had no obvious significance on statistics, others were significant. Comparing with the expression of typeⅠcollagen, except group C and E, B and G, F and G, result of others had obvious significance on statistics showing as P<0.05.

CONCLUSION: The scaring of filter canal after glaucoma surgery is main cause of the filtration surgery's failure assuming abnormal backup intraocular pressure. The effective componment 2 of Qing Guang An and MMC can obviously inhibit the multiplication of inoblast and the expression of typeⅠcollagen, reduce the hyperplasia of scar tissue, which has obvious effect for preventing scarring of filtration canal.