pISSN 2093-2340   eISSN 2092-6448
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    Infect Chemother. 2011 Dec;43(6):490-493. Korean.
    Published online Dec 30, 2011.
    https://doi.org/10.3947/ic.2011.43.6.490
    Copyright © 2011 by The Korean Society of Infectious Diseases and Korean Society for Chemotherapy
    Case Report

    A Case of Burkholderia cepacia Bacteremia and Infective Spondylitis, Treated with Ceftazidime and Trimethoprim-Sulfamethoxazole Combination Therapy, which did not Respond to Carbapenem Monotherapy

    Mi Ok Jang,1 Hyun Wook Kang,1 Seong Eun Kim,1 Seung-Ji Kang,1 Hee-Chang Jang,1 Sook-In Jung,1 Jong Hee Shin,2 and Kyung Hwa Park1
      • 1Department of Internal Medicine, Chonnam National University Medical School, Gwang-ju, Korea.
      • 2Department of Laboratory Medicine, Chonnam National University Medical School, Gwang-ju, Korea.
    • Correspondence to Kyung Hwa Park, M.D. Department of Infectious disease, Chonnam National University Medical School, 8 Hak-dong, Dong-gu, Gwangju 501-757, Korea. Tel: +82-62-220-6483, Fax: +82-62-225-8578, Email: medkid@dreamwiz.com
    Received June 21, 2011; Revised September 20, 2011; Accepted September 26, 2011.

    This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

    Abstract

    Burkholderia cepacia is an aerobic gram-negative rod that causes healthcare-associated infections through contaminated disinfectants, fluids, and medical equipment. This bacterium shows resistance to various antibiotics. For this reason, available therapeutic antimicrobial agents are limited, and the optimal antimicrobial therapeutic regimen was still not well-determined in the case of infective spondylitis. We experienced a case of B. cepacia bacteremia with infective spondylitis and paraspinal abscesses which did not respond to carbapenem monotherapy, but was did respond to ceftazidime and sulfamethoxzaole/trimethoprim combination therapy.

    Keywords
    Burkholderia cepacia; Spondylitis

    Figures

    Figure 1
    Magnetic resonance imaging of the lumbar spine. Infective spondylitis involving L3-4, small paraspinal abscess pockets, and epidural and paraspinal soft tissue thickening was evident.

    Figure 2
    Course of the patient's hospital stay. On hospital day 13, meropenem was changed to ceftazidime plus sulfamethoxazole/trimethoprim. Then WBC count, CRP level, and fever of the patient was improved.

    WBC, white blood cell; CRP, c-reactive protein; BT, body temperature; CFZOL, cefazolin; MRPN, meropenem; CFTAZ, ceftazidime; SMX/TMP, sulfamethoxazole/trimethoprim.

    Tables

    Table 1
    Clinical Findings and Management in Previous Case Reports of Spondylitis by Burkholderia species Infection

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    MeSH Terms
    Abscess
    Anti-Bacterial Agents
    Anti-Infective Agents
    Bacteremia
    Burkholderia
    Burkholderia cepacia
    Ceftazidime
    Disinfectants
    Spondylitis
    Trimethoprim, Sulfamethoxazole Drug Combination
    Metrics
    Share
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