pISSN 2093-2340   eISSN 2092-6448
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    Infect Chemother. 2010 Aug;42(4):257-261. Korean.
    Published online Aug 30, 2010.
    https://doi.org/10.3947/ic.2010.42.4.257
    Copyright © 2010 by The Korean Society of Infectious Diseases and Korean Society for Chemotherapy
    Case Report

    Three Reinfection Cases of the Pandemic Influenza (H1N1 2009)

    Tae Suk Kim,1 Kang Myung Ho,1 Kyung Ree Yim,1 Won Sup Oh,1 Sung Bin Chon,2 Sook-Won Ryu,3 Kilsoo Yie,4 and Seung-Joon Lee1
      • 1Department of Internal Medicine, Kangwon National University College of Medicine, Chuncheon, Korea.
      • 2Department of Emergency Medicine, Kangwon National University College of Medicine, Chuncheon, Korea.
      • 3Department of Laboratory Medicine, Kangwon National University College of Medicine, Chuncheon, Korea.
      • 4Department of Cardiothoracic Surgery, Kangwon National University College of Medicine, Chuncheon, Korea.
    • Correspondence to Won Sup Oh, M.D., Ph.D. Division of Infectious Diseases, Department of Internal Medicine, Kangwon National University Hospital, Kangwon National University College of Medicine, 26 Kanwondaehakgil, Chuncheon 200-947, Korea. Tel: +82-33-258-2456, Fax: +82-33-258-9471, Email: wsoh@kangwon.ac.kr
    Received April 18, 2010; Revised June 09, 2010; Accepted June 10, 2010.

    This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

    Abstract

    Infection with influenza virus results in acquisition of immunity, preventing reinfection with the homologous virus. Although reinfection following primary infection is rare, its incidence depends on immunity of human body, antigenic diversity of influenza virus, and the presence of outbreak in the community. During the pandemic influenza (H1N1 2009), a child and two women were reinfected by H1N1 influenza virus several weeks after the primary infection, and they were successfully treated again by oseltamivir. This case series will provide additional information on diagnosis, treatment, and prevention of the pandemic influenza (H1N1 2009).

    Keywords
    Pandemic influenza (H1N1 2009); Reinfection; Immunity

    Figures

    Figure 1
    (A) Electrophoresis of PCR products of cDNA after neuraminidase gene sequencing from the 2009 H1N1 influenza virus RNA. (B) Alignment results of genome segment 6 of the 2009 H1N1 influenza virus.

    1, first episode of case 1; 2, second episode of case 1; 3, first episode of case 2; 4, second episode of case 2; 5, first episode of case 3; 6, second episode of case 3; L, 100 bp ladder; N, negative control. Red-lined box indicates H275Y mutation site, which is conserved in all samples of 3 cases.

    Tables

    Table 1
    Summary of Three Reinfection Cases of the 2009 H1N1 Influenza

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    MeSH Terms
    Antigenic Variation
    Child
    Female
    Human Body
    Humans
    Incidence
    Influenza, Human
    Orthomyxoviridae
    Oseltamivir
    Pandemics
    Viruses
    Metrics
    Share
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