pISSN 2093-2340   eISSN 2092-6448
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    Infect Chemother. 2010 Aug;42(4):241-243. Korean.
    Published online Aug 30, 2010.
    https://doi.org/10.3947/ic.2010.42.4.241
    Copyright © 2010 by The Korean Society of Infectious Diseases and Korean Society for Chemotherapy
    Case Report

    A Case of Arcanobacterium haemolyticum Bacteremia and Osteomyelitis Diagnosed by 16s rRNA Sequencing

    Soo Young Bae,1 Soomi Choi,1 Seung-Ji Kang,1 Hee-Chang Jang,1 Kyung Hwa Park,1 Sook-In Jung,1 and Jong-Hee Shin2
      • 1Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
      • 2Department of Laboratory Medicine, Chonnam National University Medical School, Gwangju, Korea.
    • Correspondence to Hee-Chang Jang, M.D. Department of Internal Medicine, Chonnam National University Hospital, 671, Jebong-ro, Dong-gu, Gwangju 501-757, Korea. Tel: +82-62-220-6296, Fax: +82-62-225-8578, Email: haroc153@naver.com
    Received November 13, 2009; Revised January 13, 2010; Accepted March 24, 2010.

    This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

    Abstract

    Arcanobacterium haemolyticum is a catalase-negative, aerobic gram-positive rod. It causes pharyngitis, skin and soft tissue infection, osteomyelitis, endocarditis, meningitis, pneumonia, and septicemia. We experienced a case of A. haemolyticum bacteremia and osteomyelitis in a diabetic patient. The organism was misidentified as Cellulomonas species by automated system but correctly identified as A. haemolyticum by 16s rRNA sequencing.

    Keywords
    Arcanobacterium; Bacteremia; Sequence analysis; RNA

    Figures

    Figure 1
    Findings of osteomyelitis in tri-phase bone scan. Bony uptake of left 1st proximal and distal phalanges is not observed in delayed phase image. Increased uptakes of left 1st metatarsal bone head, tarsal bone, and upper portion of calcaneous are observed in delayed phase image.

    Figure 2
    Reverse CAMP test. Arcanobacterium haemolyticum is streaked horizontally and Staphylococcus aureus ATCC 26923 was streaked vertically. The inhibition zone of hemolysis of Staphylococcus ATCC 25923 is noted near the streak line of Arcanobacterium haemolyticum.

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    MeSH Terms
    Arcanobacterium
    Bacteremia
    Cellulomonas
    Endocarditis
    Humans
    Meningitis
    Osteomyelitis
    Pharyngitis
    Pneumonia
    RNA
    Sepsis
    Sequence Analysis
    Skin
    Soft Tissue Infections
    Metrics
    Share
    Figures
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