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    Infect Chemother. 2008 Mar-Apr;40(2):76-82. Korean.
    Published online Apr 20, 2008.
    https://doi.org/10.3947/ic.2008.40.2.76
    Copyright © 2008 The Korean Society of Infectious Diseases and The Korean Society for Chemotherapy
    Review

    Diagnosis and Treatment of Cervical Lymphadenitis from a Standpoint of Infectious Disease Specialists

    Joon Young Song, M.D. and Hee Jin Cheong, M.D.
      • Division of Infectious Disease, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
    • Correspondence: Hee Jin Cheong, M.D. Division of Infections Disease, Department of internal Medicine, Korea University College of Medicine, 37, Guro-gu, Seoul 152-703, Korea. Tel: 82-2-2626-3050, Fax: 82-2-837-1966, Email: heejinmd@medimail.co.kr
    Received March 20, 2007; Accepted April 10, 2008.

    This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

    Abstract

    Cervical lymphadenitis is one of the common causes which make the patients visit the outpatient clinic. Extensive differential diagnoses are required to identify causative illness including viral or bacterial infection, Kikuchi's disease, tuberculosis, etc. In this review, several important key points are discussed with regards to clinical course, pathological diagnosis and treatment in patients with cervical lymphadenitis.

    Keywords
    Cervical lymphadenitis; Pathology; Treatment

    Tables

    Table 1
    Cervical Lymphadenitis Requiring Biopsy

    Table 2
    Sensitivity and Specificity of FNA-based Diagnostic Methods for Tuberculous Lymphadenitis

    Table 3
    Clinical and Radiological Comparison among Tuberculous Lymphadenitis, Histiocytic Necrotizing Lymphadenitis and Reactive Lymphadenitis

    References

      1. Kubota T. The evaluation of peripheral adenopathy. Primary Care 1980;7:461.
      1. Habermann TM, Steensma DP. Lymphadenopathy. Mayo Clin Proc 2000;75:723.
      1. Moore SW, Schneider JW, Schaaf HS. Diagnostic aspects of cervical lymphadenopathy in children in the developing world: a study of 1,877 surgical specimens. Pediatr Surg Int 2003;19:240–244.
      1. Williamson HA Jr. Lymphadenopathy in a family practice: A descriptive study of 240 cases. J Fam Pract 1985;20:449.
      1. Song JY, Cheong HJ, Kee SY, Lee J, Sohn JW, Kim MJ, Seo SI, Kim IS, Kim WJ. Disease spectrum of cervical lymphadenitis: analysis based on ultrasoundguided core-needle gun biopsy. J Infect 2007;55:310–316.
      1. Ferrer R. Lymphadenopathy: Differential diagnosis and evaluation. Am Fam Physician 1998;58:1313.
      1. Lee JY, Kang JS, Kim MK, Hwang TS, Kwak YG, Chae MB, Jang CS, Kim IK, Seo DB, Chung MH. The Prevalence of Bartonella henselae Infection in Korean Feral Cats. Korean J Infect Dis 2001;33:319–324.
      1. Chung JY, Han TH, Kim BN, Yoo YS, Lim SJ. Detection of bartonella henselae DNA by polymerase chain reaction in a patient with cat scratch disease: A case report. J Korean Med Sci 2005;20:888–891.
      1. Kim EK, Kwak JY, You JK, Park CS, Chung WY, Yang WI, Oh KK. Usefullness of ultrasound-guided core needle biopsy in the diagnosis of cervical lymphadenopathy. J Korean Soc Med Ultrasound 2003;22:233–238.
      1. Cho DI. Tuberculous cervical lymphadenitis. Tuberc Respir Dis 1997;44:957–963.
      1. Lai KK, Stottmeier KD, Sherman IH, McCabe WR. Mycobacterial cervical lymphadenopathy. Relation of etiologic agents to age. JAMA 1984;251:1286–1288.
      1. Wolinsky E. Mycobacterial lymphadenitis in children: a prospective study of 105 nontuberculous cases with long-term follow-up. Clin Infect Dis 1995;20:954–963.
      1. Schaad UB, Votteler TP, McCracken GH Jr, Nelson JD. Management of atypical mycobacterial lymphadenitis in childhood: a review based on 380 cases. J Pediatr 1997;95:356–360.
      1. Ord RF, Matz GJ. Tuberculous cervical lymphadenitis. Arch Otolaryngol 1974;99:327–329.
      1. Artenstein AW, Kim JH, Williams WJ, Chung RC. Isolated peripheral tuberculous lymphadenitis in adults: current clinical and diagnostic issues. Clin Infect Dis 1995;20:876–882.
      1. Kidane D, Olobo JO, Habte A, Negesse Y, Aseffa A, Abate G, Yassin MA, Bereda K, Harboe M. Identification of the causative organism of tuberculous lymphadenitis in ethiopia by PCR. J Clin Microbiol 2002;40:4230–4234.
      1. Baek CH, Kim SI, Ko YH, Chu KC. Polymerase chain reaction detection of Mycobacterium tuberculosis from fine-needle aspirate for the diagnosis of cervical tuberculous lymphadenitis. Laryngoscope 2000;110:30–34.
      1. Kim SS, Chung SM, Kim JN, Lee MA, Ha EH. Application of PCR from the fine needle aspirates for the diagnosis of cervical tuberculous lymphadenitis. J Korean Med Sci 1996;11:127–132.
      1. Rimek D, Tyagi S, Kappe R. Performance of an IS6110-based PCR assay and the COBAS AMPLICOR MTB PCR system for detection of Mycobacterium tuberculosis complex DNA in human lymph node samples. J Clin Microbiol 2002;40:3089–3092.
      1. Yassin MA, Olobo JO, Kidane D, Negesse Y, Shimeles E, Tadesse A, Demissie A, Britton S, Harboe M, Aseffa A, Abate G. Diagnosis of tuberculous lymphadenitis in Butajira, rural Ethiopia. Scand J Infect Dis 2003;35:240–243.
      1. Aljafari AS, Khalil EA, Elsiddig KE, El Hag IA, Ibrahim ME, Elsafi ME, Hussein AM, Elkhidir IM, Sulaiman GS, Elhassan AM. Diagnosis of tuberculous lymphadenitis by FNAC, microbiological methods and PCR: a comparative study. Cytopathology 2004;15:44–48.
      1. Manitchotpisit B, Kunachak S, Kulapraditharom B, Sura T. Combined use of fine needle aspiration cytology and polymerase chain reaction in the diagnosis of cervical tuberculous lymphadenitis. J Med Assoc Thai 1999;82:363–368.
      1. Memish ZA, Mah MW, Mahmood SA, Bannatyne RM, Khan MY. Clinico-diagnostic experience with tuberculous lymphadenitis in Saudi Arabia. Clin Microbiol Infect 2000;6:137–141.
      1. Singh KK, Muralidhar M, Kumar A, Chattopadhyaya TK, Kapila K, Singh MK, Sharma SK, Jain NK, Tyagi JS. Comparison of in house polymerase chain reaction with conventional techniques for the detection of Mycobacterium tuberculosis DNA in granulomatous lymphadenopathy. J Clin Pathol 2000;53:355–361.
      1. Kim JH. Bacille Calmette-Guerin (BCG) and tuberculin skin test. Infect and Chemother 2004;36 Suppl2:S117–S123.
      1. Wang L, Turner MO, Elwood RK, Schulzer M, FitzGerald JM. A meta-analysis of the effect of Bacille Calmette Guérin vaccination on tuberculin skin test measurements. Thorax 2002;57:804–809.
      1. Kang YA, Lee HW, Yoon HI, Cho B, Han SK, Shim YS, Yim JJ. Discrepancy between the tuberculin skin test and the whole-blood interferon gamma assay for the diagnosis of latent tuberculosis infection in an intermediate tuberculosis-burden country. JAMA 2005;293:2756–2761.
      1. Kim MJ. Diagnosis and Treatment of Extrapulmonary Tuberculosis. Infect and Chemother 2004;36 Suppl2:S124–S131.
      1. Campbell IA, Dyson AJ. Lymph node tuberculosis: a comparison of treatments 18 months after completion of chemotherapy. Tubercle 1979;60:95–98.
      1. British Thoracic Society Research Committee. Short course chemotherapy for tuberculosis of lymph nodes: a controlled trial. Br Med J 1985;290:1106–1108.
      1. Jung DS, Kwon KT, Cheong HS, Rhee JY, Shin SY, Oh WS, Ko KS, Peck KR, Lee NY, Song JH. Clinical characteristics and predictive factors of paradoxical response with cervical lymph node tuberculosis in non-HIV-infected adult patients. Infect and Chemother 2006;38 Suppl2:S219.
      1. Cheng VC, Ho PL, Lee RA, Chan KS, Chan KK, Woo PC, Lau SK, Yuen KY. Clinical spectrum of paradoxical deterioration during antituberculosis therapy in non-HIV-infected patients. Eur J Clin Microbiol Infect Dis 2002;21:803–809.
      1. Bosch X, Guilabert A. Kikuchi-Fujimoto disease. Orphanet J Rare Dis 2006;1:18–20.
      1. Kuo TT. Kikuchi's disease (histiocytic necrotizing lymphadenitis): a clinico-pathological study of 79 cases with an analysis of histologic subtypes, immunohistology and DNA ploidy. Am J Surg Pathol 1995;19:798–809.
      1. Takano Y, Saegusa M, Okudaira M. Pathologic analyses of non-overt necrotizing type Kikuchi and Fujimoto's disease. Acta Pathol Jpn 1993;43:635–645.
      1. Mohanty SK, Arora R, Saha M. Kikuchi-Fujimoto disease: an overview. J Dermatol 2002;29:10–14.
      1. Yasukawa K, Matsumura T, Sato-Matsumura KC. Kikuchi's disease and the skin: case report and review of the literature. Br J Dermatol 2001;144:885–889.
      1. Tong TR, Chan OW, Lee KC. Diagnosing Kikuchi disease on fine needle aspiration biopsy: a retrospective study of 44 cases diagnosed by cytology and 8 by histopathology. Acta Cytol 2001;45:953–957.
      1. Choi JW, Lee JH, Chae YS, Kim I. The clinicopathologic analysis of Kikuchi's lymphadenitis. Korean J Pathol 2004;38:289–294.
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    MeSH Terms
    Ambulatory Care Facilities
    Bacterial Infections
    Communicable Diseases
    Diagnosis, Differential
    Histiocytic Necrotizing Lymphadenitis
    Humans
    Lymphadenitis
    Specialization
    Tuberculosis
    Metrics
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    Tables
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