Metabolomic profile of response to supplementation with β-carotene in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study123
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From the Nutritional Epidemiology Branch (AMM, SCM, SJW, and DA) and the Biostatistics Branch (JNS), Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD; Metabolon, Inc, Durham, NC (AME and EDK); and the Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland (JV).
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Supported by the Intramural Research Program of the National Cancer Institute, NIH, US Public Health Service (grant nos. N01-CN-45165, N01-RC-45035, N01-RC-37004, HHSN261201000006C, and HHSN261200800001E).
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Address correspondence to D Albanes, 9609 Medical Center Drive, 6E342, Bethesda, MD 20892-9704. E-mail: [email protected].
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Abbreviations used: ATBC, Alpha-Tocopherol, Beta-Carotene Cancer Prevention; CYP, cytochrome P450; GC, gas chromatography; LIMS, laboratory information management system; MS, mass spectroscopy; QC, quality control; UPLC/MS/MS2, ultraHPLC tandem mass spectroscopy.