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AIMS Microbiology

2022, Volume 8, Issue 2: 125-137. doi: 10.3934/microbiol.2022011
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Methicillin-resistant Staphylococcus aureus as a cause of chronic wound infections: Alternative strategies for management

  • 1.
    Clinic of Dermatology, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy
  • 2.
    Clinic of Infectious Diseases, Department of Biomedical Sciences and Public Health, Polytechnic University of Marche, Ancona, Italy
  • O.S. & S.M. equally contributed to the manuscript.
  • Received: 01 December 2021 Revised: 11 March 2022 Accepted: 06 April 2022 Published: 24 April 2022

  • Biofilm formation at the level of a wound plays an important role in its chronicization. The difficulty of its eradication has driven research toward the discovery and synthesis of new molecules that can act on biofilm to promote wound healing. This narrative review focuses on alternative molecules that can act and promote the eradication of methicillin-resistant Staphylococcus aureus, taking into consideration its antibiotic resistance, virulence, tendency toward the tenacious colonization of wounds by biofilms, and its increased prevalence in both community and hospital settings. A selection of promising studies were reported, analyzing the in vitro and/or in vivo efficacy of bacteriophages, metal nanoparticles, RNAIII inhibiting peptide (RIP), synthetized RIP derivatives, proteinase K and hamamelitannin.

    Citation: Oriana Simonetti, Samuele Marasca, Matteo Candelora, Giulio Rizzetto, Giulia Radi, Elisa Molinelli, Lucia Brescini, Oscar Cirioni, Annamaria Offidani. Methicillin-resistant Staphylococcus aureus as a cause of chronic wound infections: Alternative strategies for management[J]. AIMS Microbiology, 2022, 8(2): 125-137. doi: 10.3934/microbiol.2022011

    Related Papers:

  • Biofilm formation at the level of a wound plays an important role in its chronicization. The difficulty of its eradication has driven research toward the discovery and synthesis of new molecules that can act on biofilm to promote wound healing. This narrative review focuses on alternative molecules that can act and promote the eradication of methicillin-resistant Staphylococcus aureus, taking into consideration its antibiotic resistance, virulence, tendency toward the tenacious colonization of wounds by biofilms, and its increased prevalence in both community and hospital settings. A selection of promising studies were reported, analyzing the in vitro and/or in vivo efficacy of bacteriophages, metal nanoparticles, RNAIII inhibiting peptide (RIP), synthetized RIP derivatives, proteinase K and hamamelitannin.


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    Conflict of interest


    All authors declare no conflicts of interest.

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