Authors : P.A.O. Adeniyi, O.K. Ghazal, A.A. Musa and E.A. Caxton-Martins
Abstract: The neurobehavioural effects of ethanolic leaf extract and smoke of N. tabacum was evaluated. About 24 presumably healthy animals were randomly divided into 6 groups, A-F of 4 mice each. Groups A and B were force fed with 10.72 and 5.36 mg of ethanolic extract per kg body weight, respectively groups C and D were exposed to 10. 72 and 5.36 mg of tobacco smoke for 3 min, respectively group E was exposed to equal weight (0.02 g) of cotton wool smoke for 3 min while group F was also given equal amount (0.2 mL) of normal saline for 21 days. The treated groups exhibited some behavioral changes such as restlessness, aggressiveness, agitation and disorientation. The neurobehavioural investigation was carried out using elevated plus maze. The results suggested that the consumption of N. tabacum leaves smoke and ethanolic extract can alter neurobehavioural activities.
P.A.O. Adeniyi, O.K. Ghazal, A.A. Musa and E.A. Caxton-Martins, 2010. The Neurobehavioural Effects of Smoke and Ethanolic Extract of Nicotiana tabacum Leaves Exposure in Mice. Research Journal of Animal Sciences, 4: 99-102.