Korean J Med > Volume 89(1); 2015 > Article
류마티스
The Korean Journal of Medicine 2015;89(1):122-126.
Published online July 1, 2015.
DOI: https://doi.org/10.3904/kjm.2015.89.1.122   
A Case of Rheumatoid Arthritis Accompanied by Thrombotic Thrombocytopenic Purpura
Sung Min Kang, Ji Hyun Lee, In Hye Ku, Hae Koo Kim, Kyoung Sik Nam, Suk Ki Park
Division of Rheumatology, Department of Internal Medicine, Maryknoll Medical Center, Busan, Korea
류마티스관절염 환자에서 동반된 혈전혈소판감소자색반병 1예
강성민, 이지현, 구인혜, 김해구, 남경식, 박석기
메리놀병원 류마티스내과
Correspondence: 
Ji Hyun Lee, Tel: +82-51-461-2469, Fax: +82-51-441-6950, Email: ete@lycos.co.kr
Received: 28 November 2014   • Revised: 17 December 2014   • Accepted: 29 December 2014
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Thrombotic thrombocytopenic purpura (TTP) is a blood coagulation disorder that damages numerous organs, including the kidney, heart and brain. Features indicative of TTP include thrombocytopenia, microangiopathic hemolytic anemia, neurologic symptoms, kidney failure and fever. Infections, toxins, pregnancy and, rarely, autoimmune diseases are all known to be associated with TTP. We encountered a rare case of rheumatoid arthritis accompanied by TTP following tympanoplasty. The patient’s confusion, thrombocytopenia and renal failure all improved after plasmapheresis and high-dose glucocorticoid therapy, but she eventually expired due to sepsis. We report on this case herein and also review the relevant literature.
Key Words: Thrombotic thrombocytopenic purpura; Rheumatoid arthtiris; Plasmapheresis
주제어: 혈전혈소판감소자색반병; 류마티스관절염; 혈장분리교환술


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