Korean J Med > Volume 87(2); 2014 > Article
The Korean Journal of Medicine 2014;87(2):219-223.
Published online August 1, 2014.
DOI: https://doi.org/10.3904/kjm.2014.87.2.219   
Dioscorea Quinqueloba-Induced Tubulointerstitial Nephritis
Ji Min Jeon1, Yong Ki Park1, Mi Young Jeon2
1Department of Internal Medicine, Dongrae Bong Seng Hospital, Busan, Korea
2Department of Pathology, Maryknoll Medical Center, Busan, Korea
단풍마 복용 후 발생한 세뇨간질성 신염
전지민1, 박용기1, 전미영2
1동래봉생병원 신장내과
2메리놀병원 병리과
Correspondence: 
Ji Min Jeon, Tel: +82-51-520-5622, Fax: +82-51-520-5639, Email: 59356815@hanmail.net
Received: 11 November 2013   • Revised: 3 December 2013   • Accepted: 7 January 2014
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Drug-induced tubulointerstitial nephritis is one cause of acute kidney injury. Although traditional remedies have been widely used in South Korea, Dioscorea quinqueloba-induced tubulointerstitial nephritis has not been reported in the general population. A 72-year-old male patient was transferred to our hospital with pulmonary edema, oliguria, decreased mentality, severe generalized edema after taking D. quinqueloba 25 days ago. His initial lab findings showed a blood urea nitrogen level of 43.4 mg/dL, a creatinine level of 5.3 mg/dL. Urinalysis revealed SG (1.015), blood (many), protein (++) and WBC (0-3/HPF). Kidney biopsy demonstrated severe mononuclear cell infiltration into the renal interstitium with mild tubular atrophy. Aggressive renal replacement therapy and supportive care resulted in gradual restoration of his renal function. This case implies that D.
Key Words: Dioscorea quinqueloba; Tubulointerstitial nephritis; Acute kidney injury
주제어: 단풍마; 세뇨간질성 신염; 급성신부전


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