A 20-year-old woman presented with an 8-month history of lower abdominal pain, diarrhea, and 4-kg weight loss. She had no documented medical history. Physical examination showed tenderness around the periumbilical area, multiple oral ulcers, and anal fistula. Laboratory tests revealed moderate anemia, hypoalbuminemia, and elevated C-reactive protein. Computed tomography enterography showed multiple segmental bowel wall thickening. Ileocolonoscopy disclosed multiple longitudinal ulcers. Esophagogastroduodenoscopy showed esophageal ulcers (Fig. 1A, circle), gastric antral ulcers, and an unexpected endoscopic appearance of gastric corpus: multiple shallow ulcers (0.4 to 0.6 cm) in longitudinal distributions (Fig. 1B), but no bamboo joint-like appearance at cardia. Histologic examination demonstrated focal active gastritis in the gastric corpus and epithelioid granulomas in the antrum with Helicobacter pylori negative (Fig. 2, circle). Based on clinical, radiological, endoscopic, and histological findings, the patient was diagnosed with Crohn’s disease. And the gastroscopic appearance was consistent with Crohn’s disease involving the stomach. After three cycles of induction treatment with infliximab, a repeated gastroscopy showed the esophageal ulcers and gastric ulcers were complete healing.