Polymorphisms in estrogen receptor-α are associated with idiopathic female infertility

  • Authors:
    • Jiu-Wei Du
    • Xin-Rong Tao
    • Ke-Yi Xu
    • Li-Yi Fang
    • Xin-Lan Qi
  • View Affiliations

  • Published online on: August 12, 2011     https://doi.org/10.3892/mmr.2011.551
  • Pages: 1239-1242
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Abstract

To investigate the relationship between polymorphisms in the estrogen receptor-α (ERα) gene and unexplained female infertility, restriction fragment length polymorphism (RFLP) analysis of ERα was employed in 150 females with idiopathic infertility (study group) and 150 healthy, age‑matched females of proven fertility (control group). The results showed that the ERα allele frequencies differed significantly between the study and control groups (P=0.001). The allele identified by PvuII (P) restriction was detected more frequently in the study group (49.0% of individuals) compared to the control group (31.0%; P=0.001), while the allele identified by XbaI (X) restriction was detected less frequently in the study group (19.7%) compared to the control group (35.7%, P=0.001). A similar phenomenon was observed for the distribution of the TA alleles. The TA13 allele was more common in the study group (24.7 vs. 6.7% in controls; P=0.001), while the TA15 allele was less common in the study group (15.3 vs. 27.3% in controls; P=0.034). To conclude, polymorphisms in the ERα gene are associated with idiopathic female infertility. In particular, the P and TA13 alleles may represent significant risk factors, while the X and TA15 alleles may be protective factors.

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November-December 2011
Volume 4 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Du J, Tao X, Xu K, Fang L and Qi X: Polymorphisms in estrogen receptor-α are associated with idiopathic female infertility. Mol Med Rep 4: 1239-1242, 2011
APA
Du, J., Tao, X., Xu, K., Fang, L., & Qi, X. (2011). Polymorphisms in estrogen receptor-α are associated with idiopathic female infertility. Molecular Medicine Reports, 4, 1239-1242. https://doi.org/10.3892/mmr.2011.551
MLA
Du, J., Tao, X., Xu, K., Fang, L., Qi, X."Polymorphisms in estrogen receptor-α are associated with idiopathic female infertility". Molecular Medicine Reports 4.6 (2011): 1239-1242.
Chicago
Du, J., Tao, X., Xu, K., Fang, L., Qi, X."Polymorphisms in estrogen receptor-α are associated with idiopathic female infertility". Molecular Medicine Reports 4, no. 6 (2011): 1239-1242. https://doi.org/10.3892/mmr.2011.551