Role of Cardiac Myocytes Heart Fatty Acid Binding Protein Depletion (H-FABP) in Early Myocardial Infarction in Human Heart (Autopsy Study)
DOI:
https://doi.org/10.3889/oamjms.2016.018Keywords:
detection myocardial infarction, H-FABP, immunohistochemistry, MI, sudden cardiac deathAbstract
BACKGROUND: Many immunohistochemical markers have been used in the postmortem detection of early myocardial infarction.
AIM: In the present study we examined the role of Heart-type fatty acid binding protein (H-FABP), in the detection of early myocardial infarction.
MATERIAL AND METHODS: We obtained samples from 40 human autopsy hearts with/ without histopathological signs of ischemia.
RESULTS: All cases of definite and probable myocardial infarction showed a well-defined area of H-FABP depletion. All of the control cases showed strong H-FABP expression, except two markedly autolysed myocardial samples that showed affected antigenicity.
CONCLUSION: Thus, we suggest H-FABP as being one of the valuable tools facing the problem of postmortem detection of early myocardial infarction/ischemia, but not in autolysis.Downloads
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