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The anti-melanogenic effects of Petalonia binghamiae extracts in α-melanocyte stimulating hormone-induced B16/F10 murine melanoma cells

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Abstract

Petalonia binghamiae extracts (PBE) suppressed melanin synthesis in a dose-dependent manner in α-melanocyte stimulating hormone (α-MSH)-treated B16/F10 murine melanoma cells. Specifically, the cell tyrosinase activity and melanin content were inhibited by 72% and 48%, respectively, in response to treatment with 100 μg/mL of PBE. The results of western blot analysis suggest that PBE induced the inhibition of tyrosinase and TRP-1 protein expression through suppression of α-MSH induced p38 and ERK activation.

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Abbreviations

ERK:

extracellular signal-regulated kinase

α-MSH:

α-melanocyte stimulating hormone

MTT:

3-(4, 5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide

PBE:

Petalonia Binghamiae extracts

TRP:

tyrosinase-related protein

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Authors and Affiliations

  1. Subtropical Horticulture Research Institute, 690-756, Jeju, Republic of Korea

    Hoon Seok Yoon & In-Jung Kim

  2. Faculty of Biotechnology, College of Applied Life Sciences, 690-756, Jeju, Republic of Korea

    Won Beom Koh & In-Jung Kim

  3. Research Institute for Subtropical Agriculture and Biotechnology, 690-756, Jeju, Republic of Korea

    In-Jung Kim

  4. Biotechnology Regional Innovation Center, Jeju National University, 690-756, Jeju, Republic of Korea

    You-Sung Oh

Authors
  1. Hoon Seok Yoon
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  2. Won Beom Koh
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  3. You-Sung Oh
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  4. In-Jung Kim
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Correspondence to In-Jung Kim.

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Yoon, H.S., Koh, W.B., Oh, YS. et al. The anti-melanogenic effects of Petalonia binghamiae extracts in α-melanocyte stimulating hormone-induced B16/F10 murine melanoma cells. J. Korean Soc. Appl. Biol. Chem. 52, 564–567 (2009). https://doi.org/10.3839/jksabc.2009.095

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  • DOI: https://doi.org/10.3839/jksabc.2009.095

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