Abstract
Rats were trained on a one-way jump avoidance task prior to and following electrically induced hippocampal electrographic seizures. Rats trained when normal did not perform a jump avoidance response following seizures, but avoidance recovered within 24 h. When rats were trained immediately following seizures, the response did not transfer to the normal condition. Performance on two-choice brightness and pattern discriminations were not disrupted by seizures. It is suggested that seizures disrupt normal hippocampal function in the control of movement and that disruption and hence “state-dependent” effects occur on tasks in which the primary measure of performance involves movement.
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ADEY, W. R., & DUNLOP, C. W. The action of certain cyclohexamines on hippocampal system during approach performance in the cat. Journal of Pharmacological & Experimental Therapeutics, 1960, 130, 418–426.
BARONDES, S. H., & COHEN, H. D. Puromycin effect on successive phases of memory storage. Science, 1966, 151, 594–595.
BARONDES, S. H., & COHEN, H. D. Comparative effects of cycloheximide and puromycin on cerebral protein synthesis and consolidation of memory in mice. Brain Research, 1967, 4, 44–51.
BLAND, B. H., & VANDERWOLF, C. H. Effects of dentate gyrus stimulation on behavior and hippocampal electrical activity. Proceedings of the Canadian Federation of Biological Societies, 1970b, 13, 47.
COHEN, H. D., ERVIN, E. F., & BARONDES, S. H. Puromycin and cyclohexamide: Different effects on hippocampal electrical activity. Science, 1966, 154, 1557–1558.
CREUTZFELDT, O. D., & MEYER-MICKELEIT, R. W. Patterns of convulsive discharges of the hippocampus and their propagation. Electroencephalography & Clinical Neurophysiology, 1953, Supplement 3, 43.
DELGADO, J. M. R., & SEVILLANO, M. Evolution of repeated hippocampal seizures in the cat. Electroencephalography & Clinical Neurophysiology, 1961, 13, 722–733.
FLYNN, J. P. & WASMAN, M. Learning and cortically evoked movement during propagated hippocampal after discharges. Science, 1960, 131, 1607–1608.
GLICKMAN, S. E., HIGGINS, T., & ISAACSON, R. L. Some effects of hippocampal lesions on the behavior of Mongolian gerbils. Physiology & behavior, 1970, 5, 931–938.
KAADA, B. R. Somato-motor, autonomic and eie c troc o rtic o graphic responses to electrical stimulation of “rhinencephalic” and other structures in primates, cat and dog. Acta Physiologica Scandinavica, 1951, 24, Supplement 83, 185.
KIM, C, CHOI, H., KIM, J. K., CHANG, H. K., PARK, R. S., & KANG, L. Y. General behavioral activity and its component patterns in hippocampectomized rats. Brain Research, 1970, 19, 379–394.
LIDSKY, T. I., LEVINE, M. S., KREINICK, C. J., & SCHWARTZBAUM, J. S. Retrograde effects of amygdaloid stimulation on conditioned suppression (CER) in rats. Journal of Comparative & Physiological Psychology, 1970, 73, 135–149.
MacLEAN, P. D., FLANIGAN, S., FLYNN, J. P., KIM, C, & STEVENS, J. R. Hippocampal function: Tentative correlations of conditioning, EEG, drug, and radio autographic studies. Yale Journal of Biology & Medicine, 1955-56, 28, 380–395.
OLTON, D. S. Specific deficits in active avoidance behavior following penicillin injections into hippocampus. Physiology & behavior, 1970, 5, 957–963.
OVERTON, D. Dissociated learning in drug states (state dependent learning). In D. H. Efron (Ed.), Psychopharmacology: A review of progress, 1957–1967. Washington, D.C: United States Public Health Service, 1968.
THOMPSON, R., & BRYANT, J. H. Memory as affected by activity of the relevant receptor. Psychological Reports, 1955, 1, 393–400.
THOMPSON, R., & MASSOPUST, L. C, Jr. The effect of subcortical lesion on retention of a brightness discrimination in rats. Journal of Comparative & Physiological Psychology, 1960, 53, 488–496.
VANDERWOLF, C. H. Hippocampal electrical activity and voluntary movement in the rat. Electroencephalography & Clinical Neurophysiology, 1969, 26, 407–418.
VANDERWOLF, C. H. Limbic-diencephalic relations in higher level control of movement. Psychological Review, 1971, 78, 83–113.
VANDERWOLF, C. H., BLAND, B. H., & WHISHAW, I. Q. Diencephalic, hippocampal and neocortical mechanisms in voluntary behavior. In J. Maser (Ed.), Efferent organization and the integration of behavior. New York: Academic Press, 1971, in press.
WHISHAW, I. Q. Comparative studies of the relation of hippocampal electrical activity to behavior. Unpublished PhD thesis, University of Western Ontario, London, Ont., Canada, 1971.
WHISHAW, I. Q., & VANDERWOLF, C. H. Hippocampal correlates of movement. Proceedings of the Canadian Federation of Biological Sciences, 1970, 13, 48.
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This research was supported by Grant 28–1108 from the University of Lethbridge, Lethbridge, Alta., Canada
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Whishaw, I.Q., Deatherage, G. The effects of hippocampal electrographic seizures on one-way active avoidance and visual discrimination in rats: State-dependent effects. Psychon Sci 25, 129–133 (1971). https://doi.org/10.3758/BF03332472
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DOI: https://doi.org/10.3758/BF03332472