Abstract
The hippocampal commissure was stimulated in 35 rats in order to find conditions which favor triggering of motor seizures on the first trial. Strain and supplier of rats, size and orientation of electrodes, distance between electrode poles, area of the commissure stimulated, ongoing behavior, pattern of electrical activity in the hippocampus, and state of arousal were varied. In each case, motor seizures developed only after many daily stimulations, as reported for other limbic sites. However, stimulation of corpus callosum or cingulum yielded motor seizures on the first trial. It is concluded that previous reports of first-trial motor seizures triggered from the hippocampal commissure (Racine et al., 1972) must have resulted from stimulation which encroached upon these more dorsal structures. The results suggest that kindling may not be restricted to the strengthening of limbic-limbic connections but may also require modification of circuits lying more distal to the limbic system.
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Arnold, P. S., Racine, R. J., & Wise, R. A. Effects of atropine, reserpine, 6-hydroxydopamine, and handling on seisure development in the rat. Experimental Neurology, 1973, 40, 457–470.
Burnham,W. M. Epileptogenic modification of the rat forebrain by direct and trans-synaptic stimulation. PhD thesis, McGill University, 1971.
Gaito, J. The kindling effect. Physiological Psychology, 1974, 2, 45–50.
Goddard, G. V.Long term alteration following amygdaloid stimulation. In B. E. Eleftheriou (Ed.), The neurobiology of the amygdala. New York: Plenum, 1972.
Goddard, G. V., Mcintyre, D. C., & Leech, C. K. A permanent change in brain function resulting from daily electrical stimulation. Experimental Neurology, 1969, 25, 295–330.
McIntyre, D. C., & Molino, A. Amygdala lesions and CER learning: Long term effect of kindling. Physiology & Behavior, 1972, 8, 1055–1058.
Pinel, J. P. J., Phillips, A. G., & MacNeill, B. Blockage of highly-stable “kindled” seizures in rats by antecedent footshock. Epilepsia, 1973, 14, 29–37.
Racine, R. J. Modification of seizure activity by electrical stimulation: Cortical areas. Electroencephalography & Clinical Neurophysiology, 1975, 38, 1–12.
Racine, R. J., Burnham, W. M., & Gartner, J. G. First trial motor seizures triggered by amygdaloid stimulation in the rat. Electroencephalography & Clinical Neurophysiology, 1973, 35, 487–494.
Racine, R. J., Okujava, V., & Chipashvili, S. Modification of seizure activity by electrical stimulation: III. Mechanisms. Electroencephalography & Clinical Neurophysiology, 1972, 32, 295–299.
Vanderwolf, C. H. Hippocampal electrical activity and voluntary movement in the rat. Electroencephalography & Clinical Neurophysiology, 1969, 26, 407–418.
Vosu, H., & Wise, R. A. Cholinergic seizure kindling in the rat: Comparison of caudate, amygdala and hippocampus. Behavioral Biology, 1975, 13, 491–495.
Wada, J. A., & Sato, M. Generalized convulsive seizure induced by daily electrical stimulation of the amygdala in cats: Correlative electrographic and behavioral features. Neurology, 1974, 24, 565–574.
Wada, J. A., & Sato, M. The generalized convulsive seizure state induced by daily electrical stimulation of the amygdala in split brain cats. Epilepsia, 1975, in press.
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The authors wish to acknowledge Miss F. Moody and Mr. W. Lanterman for technical assistance and Drs. C. Vanderwolf and R. Racine for providing information during the running of the experiment. This research was supported by Research Grant A0365 awarded to Dr. G. V. Goddard by the National Research Council of Canada and by N.R.C. postgraduate scholarships to D. Rasmusson and F. Madryga.
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Madryga, F.J., Goddard, G.V. & Rasmusson, D.D. The kindling of motor seizures from hippocampal commissure in the rat. Psychobiology 3, 369–373 (1975). https://doi.org/10.3758/BF03326843
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DOI: https://doi.org/10.3758/BF03326843