Abstract
Induction and recovery (eduction) times were measured for recombinant inbred strains (RI strains) of mice, their reciprocal F1 hybrids and their progenitor strains. The resulting pattern of means for these groups indicated that two or more loci influence induction and eduction times. The strain distribution patterns were different for induction and eduction and for different dose levels of anesthetic. Strain differences in time to induce anesthetic effects and time to recover from anesthetic effects, as well as inadvertent use of varying anesthetic dose levels from study to study, may contribute to inconsistent results for studies of anesthetic effects on complex behavior.
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This research was supported in part by NIH Research Grant HD-05523 (to BEE) from the National Institute of Child Health and Human Development and by a research grant from the United Health Services of North Carolina to MFE. Many thanks are extended to Dr. C, Douglass Blenkarn, Department of Anesthesiology, Duke University Medical Center, for his advise and assistance in the design of the anesthetic equipment.
The Jackson Laboratory is fully accredited by the American Association for the Accreditation of Laboratory Animal Care.
An erratum to this article is available at http://dx.doi.org/10.3758/BF03201534.
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Elias, M.F., Eleftheriou, B.E. A behavior-genetic investigation of induction and eduction times for halothane anesthesia. Behavior Research Methods & Instrumentation 7, 7–10 (1975). https://doi.org/10.3758/BF03201279
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DOI: https://doi.org/10.3758/BF03201279