色谱 ›› 2016, Vol. 34 ›› Issue (1): 16-20.DOI: 10.3724/SP.J.1123.2015.09002

• 专论与综述 • 上一篇    下一篇

毛细管电泳在手性化合物分离中的应用进展

潘聪洁1,2, 王伟峰1,2, 陈兴国1,2,3   

  1. 1. 兰州大学化学化工学院, 甘肃 兰州 730000;
    2. 功能有机分子化学国家重点实验室, 甘肃 兰州 730000;
    3. 甘肃省有色金属化学与资源利用重点实验室, 甘肃 兰州 730000
  • 收稿日期:2015-09-02 出版日期:2016-01-08 发布日期:2012-08-01
  • 通讯作者: 陈兴国
  • 基金资助:

    国家自然科学基金项目(21375053).

Recent developments of chiral separation by capillary electrophoresis

PAN Congjie1,2, WANG Weifeng1,2, CHEN Xingguo1,2,3   

  1. 1. College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China;
    2. State Key Laboratory of Applied Organic Chemistry, Lanzhou 730000, China;
    3. Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Lanzhou 730000, China
  • Received:2015-09-02 Online:2016-01-08 Published:2012-08-01
  • Supported by:

    National Natural Science Foundation of China (Grant No. 21375053).

摘要:

由于手性化合物尤其是手性药物的两个对映体具有不同的化学性质和生理活性,对手性化合物进行分离在医药、生物、食品和环境等领域都具有十分重要的意义。毛细管电泳由于其独特的优势已广泛应用于手性物质的分离。本文对2013~2015年毛细管电泳用于手性分离的最新进展进行了综述,并对其发展前景进行了展望。

关键词: 进展, 毛细管电泳, 手性分离, 综述

Abstract:

As the two enantiomers of chiral compounds have different chemical and physiologic properties, the enantioseparation of chiral compounds is of great significance in the fields such as medicine, biology, food and environment. Hence, the enantioseparation of different types of chiral compounds has become one of the hottest research topics in recent years. Capillary electrophoresis, owing to its unique advantages, has a wide application in the enantioseparation field recently. In this review, the latest research progresses in capillary electrophoresis enantioseparation are summarized from 2013 to 2015, and the future developments in this field is also prospected.

Key words: capillary electrophoresis (CE), enantioseparation, progress, review

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