:+: 대한임상통증학회 :+:

19(02) 120-123

https://doi.org/10.35827/cp.2020.19.2.120

비소세포폐암 환자에서 크리조티닙 치료 후 발생한 급속 파괴형 슬관절증

황진태¹ㆍ최재형¹ㆍ박철현¹ㆍ윤경재¹ㆍ이용택¹ㆍ도종걸²

¹성균관대학교 의과대학 강북삼성병원 재활의학교실, ²성균관대학교 의과대학 삼성서울병원 재활의학교실

J Korean Assoc Pain Med 2020 Dec; 19(02) 120-123

Rapidly Destructive Arthrosis of Knee Following Treatment of Crizotinib in a Patient with Non-Small-Cell Lung Cancer

Jin Tae Hwang, M.D.¹, Jae-Hyeong Choi, M.D.¹, Chul-Hyun Park, M.D.¹, Kyung Jae Yoon, M.D., Ph.D.¹, Yong-Taek Lee, M.D., Ph.D.¹ and Jong Geol Do, M.D.²

¹Department of Physical & Rehabilitation Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, ²Department of Physical and Rehabilitation Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

Rapidly destructive arthrosis is a rare syndrome characterized by narrowing of the joint space and rapid joint destruction within 6∼12 months. A 62-year-old woman with anaplastic lymphoma kinase rearranged non-small-cell lung cancer presented with both knee pain and varus deformity. She was treated with crizotinib 500 mg/day for more than 2 years, with partial tumor response. Initial plain radiography showed Kellgren and Lawrence (K-L) grade 1. After 10 months, varus deformity was worsened and plain radiography aggravated to K-L grade 4 despite conservative treatment including activity modification. Diffuse synovitis with massive joint effusion and destruction of anterior cruciate ligament, medial meniscus, medial collateral ligament, and lateral collateral ligament were shown in magnetic resonance imaging. The patient was diagnosed with rapidly destructive arthrosis of knee and underwent a both total knee arthroplasty.

J Korean Assoc Pain Med 2020 Dec; 19(02) 120-123

Keyword : Arthrosis, Crizotinib, Non-small cell lung cancer