초록

Oncolytic virus immunotherapy represents a new class of therapeutic approach that target the cancer cells selectively and it is emerging as supportive or alternative treatment to the standard of care such as surgery, chemotherapy and radiotherapy. Its unique advantages stems from its tumor cell specific lysis along with host immune stimulation. To date, a wide variety of oncolytic viruses are evaluated for this purpose and several of them demonstrated promising clinical results. Recently, it is used in combination with other anti-cancer modalities showing more enhanced results. This article briefly describes past, current and future perspectives of oncolytic virus immunotherapy focusing on the virus type and combination agents and discusses consideration in developing oncolytic viruses as commercial therapeutic agents in field of cancer treatment.

키워드

oncolytic virus, immunotherapy, commercialization

참고문헌(78)open

  1. [학술지] Langenberg MH / 2011 / Phase I evaluation of telatinib, a VEGF receptor tyrosine kinase inhibitor, in combination with bevacizumab in subjects with advanced solid tumors / Ann Oncol 22 : 2508 ~ 2515

  2. [학술지] Tan KX / 2016 / Towards targeted cancer therapy: Aptamer or oncolytic virus? / Eur J Pharm Sci 96 : 8 ~ 19

  3. [학술지] Lolkema MP / 2011 / A phase I study of the combination of intravenous reovirus type 3 Dearing and gemcitabine in patients with advanced cancer / Clin Cancer Res 17 : 581 ~ 588

  4. [학술지] Singh PK / 2012 / Oncolytic viruses & their specific targeting to tumour cells / Indian J Med Res 136 : 571 ~ 584

  5. [학술지] Kaufman HL / 2015 / Oncolytic viruses : a new class of immunotherapy drugs / Nat Rev Drug Discov 14 : 642 ~ 662

  6. [학술지] Fukuhara H / 2016 / Oncolytic virus therapy : A new era of cancer treatment at dawn / Cancer Sci 107 : 1373 ~ 1379

  7. [학술지] Pack GT / 1950 / Note on the experimental use of rabies vaccine for melanomatosis / AMA archives of dermatology and syphilology 62 : 694 ~ 695

  8. [학술지] Kelly E / 2007 / History of oncolytic viruses : genesis to genetic engineering / Mol Ther 15 : 651 ~ 659

  9. [학술지] Huebner RJ / 1955 / Studies of adenoidal-pharyngeal-conjunctival vaccines in volunteers / J Am Med Assoc 159 : 986 ~ 989

  10. [학술지] Rowe WP / 1953 / Isolation of a cytopathogenic agent from human adenoids undergoing spontaneous degeneration in tissue culture / Proc Soc Exp Biol Med 84 : 570 ~ 573

  11. [학술지] Huebner RJ / 1956 / Studies on the use of viruses in the treatment of carcinoma of the cervix / Cancer 9 : 1211 ~ 1218

  12. [학술지] Georgiades J / 1959 / Research on the oncolytic effect of APC viruses in cancer of the cervix uteri; preliminary report / Biul Inst Med Morsk Gdansk 10 : 49 ~ 57

  13. [학술지] Zielinski T / 1969 / Remote results of clinical observation of the oncolytic action of adenoviruses on cervix cancer / Nowotwory 19 : 217 ~ 221

  14. [학술지] Southam CM / 1954 / Induced virus infections in man by the Egypt isolates of West Nile virus / Am J Trop Med Hyg 3 : 19 ~ 50

  15. [학술지] Ring CJ / 2002 / Cytolytic viruses as potential anti-cancer agents / J Gen Virol 83 : 491 ~ 502

  16. [학술지] Kreppel F / 2008 / Modification of adenovirus gene transfer vectors with synthetic polymers : a scientific review and technical guide / Mol Ther 16 : 16 ~ 29

  17. [학술지] Lawler SE / 2016 / Oncolytic Viruses in Cancer Treatment : A Review / JAMA Oncol

  18. [학술지] Di Piazza M / 2007 / Cytosolic activation of cathepsins mediates parvovirus H-1-induced killing of cisplatin and TRAIL-resistant glioma cells / J Virol 81 : 4186 ~ 4198

  19. [학술지] Guse K / 2011 / Oncolytic vaccinia virus for the treatment of cancer / Expert Opin Biol Ther 11 : 595 ~ 608

  20. [학술지] Kim JH / 2006 / Systemic armed oncolytic and immunologic therapy for cancer with JX-594, a targeted poxvirus expressing GM-CSF / Mol Ther 14 : 361 ~ 370

  21. [학술지] Dmitriev I / 1998 / An adenovirus vector with genetically modified fibers demonstrates expanded tropism via utilization of a coxsackievirus and adenovirus receptor-independent cell entry mechanism / J Virol 72 : 9706 ~ 9713

  22. [학술지] Lu YC / 2012 / Replicating retroviral vectors for oncolytic virotherapy of experimental hepatocellular carcinoma / Oncol Rep 28 : 21 ~ 26

  23. [학술지] Merrill MK / 2004 / Poliovirus receptor CD155-targeted oncolysis of glioma / Neuro Oncol 6 : 208 ~ 217

  24. [학술지] Mader EK / 2009 / Mesenchymal stem cell carriers protect oncolytic measles viruses from antibody neutralization in an orthotopic ovarian cancer therapy model / Clin Cancer Res 15 : 7246 ~ 7255

  25. [학술지] Tesfay MZ / 2013 / PEGylation of vesicular stomatitis virus extends virus persistence in blood circulation of passively immunized mice / J Virol 87 : 3752 ~ 3759

  26. [학술지] Elankumaran S / 2010 / Type I interferon-sensitive recombinant newcastle disease virus for oncolytic virotherapy / J Virol 84 : 3835 ~ 3844

  27. [학술지] Ghebremedhin B / 2014 / Human adenovirus : Viral pathogen with increasing importance / Eur J Microbiol Immunol(Bp) 4 : 26 ~ 33

  28. [학술지] Williams PD / 2010 / Development of viral vectors for use in cardiovascular gene therapy / Viruses 2 : 334 ~ 371

  29. [학술지] Trotman LC / 2001 / Import of adenovirus DNA involves the nuclear pore complex receptor CAN/Nup214 and histone H1 / Nat Cell Biol 3 : 1092 ~ 1100

  30. [학술지] Alemany R / 2009 / Designing adenoviral vectors for tumor-specific targeting / Methods Mol Biol 542 : 57 ~ 74

  31. [학술지] Dynlacht BD / 2005 / E2F and p53 make a nice couple : converging pathways in apoptosis / Cell Death and Differentiation 12 : 313 ~ 314

  32. [학술지] Berk AJ / 2005 / Recent lessons in gene expression, cell cycle control, and cell biology from adenovirus / Oncogene 24 : 7673 ~ 7685

  33. [학술지] Rao L / 1992 / The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins / Proc Natl Acad Sci U S A 89 : 7742 ~ 7746

  34. [학술지] Harada JN / 1999 / p53-Independent and-dependent requirements for E1B-55K in adenovirus type 5 replication / J Virol 73 : 5333 ~ 5344

  35. [학술지] McCormick F / 2000 / ONYX-015 selectivity and the p14ARF pathway / Oncogene 19 : 6670 ~ 6672

  36. [학술지] Au T / 2007 / Minimal hepatic toxicity of Onyx-015 : spatial restriction of coxsackie-adenoviral receptor in normal liver / Cancer Gene Ther 14 : 139 ~ 150

  37. [학술지] Khuri FR / 2000 / a controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer / Nat Med 6 : 879 ~ 885

  38. [학술지] Crompton AM / 2007 / From ONYX-015 to armed vaccinia viruses : the education and evolution of oncolytic virus development / Curr Cancer Drug Targets 7 : 133 ~ 139

  39. [학술지] Kimball KJ / 2010 / A phase I study of a tropism-modified conditionally replicative adenovirus for recurrent malignant gynecologic diseases / Clin Cancer Res 16 : 5277 ~ 5287

  40. [학술지] Jiang H / 2014 / Delta-24-RGD oncolytic adenovirus elicits anti-glioma immunity in an immunocompetent mouse model / PLoS One 9 : e97407

  41. [학술지] Kuhn I / 2008 / Directed evolution generates a novel oncolytic virus for the treatment of colon cancer / PLoS One 3 : e2409

  42. [학술지] Kaufman HL / 2010 / Local and distant immunity induced by intralesional vaccination with an oncolytic herpes virus encoding GM-CSF in patients with stage IIIc and IV melanoma / Ann Surg Oncol 17 : 718 ~ 730

  43. [학술지] Roth JC / 2014 / Evaluation of the Safety and Biodistribution of M032, an Attenuated HSV-1 Virus Expressing hIL-12, After Intracerebral Administration to Aotus Non-Human Primates / Hum Gene Ther Clin Dev

  44. [학술지] Liu BL / 2003 / ICP34.5 deleted herpes simplex virus with enhanced oncolytic, immune stimulating, and anti-tumour properties / Gene Ther 10 : 292 ~ 303

  45. [학술지] Andtbacka RH / 2015 / Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma / J Clin Oncol 33 : 2780 ~ 2788

  46. [학술지] Strong JE / 1998 / The molecular basis of viral oncolysis : usurpation of the Ras signaling pathway by reovirus / EMBO J 17 : 3351 ~ 3362

  47. [학술지] Lawson KA / 2016 / Repurposing Sunitinib with Oncolytic Reovirus as a Novel Immunotherapeutic Strategy for Renal Cell Carcinoma / Clin Cancer Res

  48. [학술지] Danthi P / 2010 / From touchdown to transcription : the reovirus cell entry pathway / Curr Top Microbiol Immunol 343 : 91 ~ 119

  49. [학술지] Errington F / 2008 / Reovirus activates human dendritic cells to promote innate antitumor immunity / J Immunol 180 : 6018 ~ 6026

  50. [학술지] Harrington KJ / 2010 / Clinical trials with oncolytic reovirus : moving beyond phase I into combinations with standard therapeutics / Cytokine Growth Factor Rev 21 : 91 ~ 98

  51. [학술지] Karapanagiotou EM / 2012 / Phase I/II trial of carboplatin and paclitaxel chemotherapy in combination with intravenous oncolytic reovirus in patients with advanced malignancies / Clin Cancer Res 18 : 2080 ~ 2089

  52. [학술지] Thirukkumaran CM / 2010 / Oncolytic viral therapy for prostate cancer : efficacy of reovirus as a biological therapeutic / Cancer Res 70 : 2435 ~ 2444

  53. [학술지] Gollamudi R / 2010 / Intravenous administration of Reolysin, a live replication competent RNA virus is safe in patients with advanced solid tumors / Invest New Drugs 28 : 641 ~ 649

  54. [학술지] Harrow S / 2004 / HSV1716 injection into the brain adjacent to tumour following surgical resection of high-grade glioma : safety data and long-term survival / Gene Ther 11 : 1648 ~ 1658

  55. [학술지] Herman JR / 1999 / In situ gene therapy for adenocarcinoma of the prostate : a phase I clinical trial / Hum Gene Ther 10 : 1239 ~ 1249

  56. [학술지] Yu P / 2005 / Intratumor depletion of CD4+ cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors / J Exp Med 201 : 779 ~ 791

  57. [학술지] Yoshihara C / 2010 / Preparation of a novel adenovirus formulation with artificial envelope of multilayer polymer-coatings : therapeutic effect on metastatic ovarian cancer / Oncol Rep 23 : 733 ~ 738

  58. [학술지] Liu WH / 2015 / Combination of exosomes and circulating microRNAs may serve as a promising tumor marker complementary to alpha-fetoprotein for early-stage hepatocellular carcinoma diagnosis in rats / J Cancer Res Clin Oncol 141 : 1767 ~ 1778

  59. [학술지] Guo H / 2013 / The regulation of Tolllike receptor 2 by miR-143 suppresses the invasion and migration of a subset of human colorectal carcinoma cells / Mol Cancer 12 : 77

  60. [학술지] Chen X / 2015 / Clinical value of integrated-signature miRNAs in colorectal cancer : miRNA expression profiling analysis and experimental validation / Oncotarget 6 : 37544 ~ 37556

  61. [학술지] Worthley DL / 2010 / Colorectal cancer : molecular features and clinical opportunities / Clin Biochem Rev 31 : 31 ~ 38

  62. [학술지] Ginn SL / 2013 / Gene therapy clinical trials worldwide to 2012-an update / J Gene Med 15 : 65 ~ 77

  63. [학술지] Luo Q / 2016 / A novel E1B55k-Da-deleted oncolytic adenovirus carrying microRNA-143 exerts specific antitumor efficacy on colorectal cancer cells / Am J Transl Res 8 : 3822 ~ 3830

  64. [학술지] Ylosmaki E / 2008 / Generation of a conditionally replicating adenovirus based on targeted destruction of E1A mRNA by a cell type-specific MicroRNA / J Virol 82 : 11009 ~ 11015

  65. [학술지] Russell SJ / 2012 / Oncolytic virotherapy / Nat Biotechnol 30 : 658 ~ 670

  66. [학술지] Jung BK / 2016 / Mild Hyperthermia Induced by Gold Nanorod-Mediated Plasmonic Photothermal Therapy Enhances Transduction and Replication of Oncolytic Adenoviral Gene Delivery / ACS Nano

  67. [학술지] Larson C / 2015 / Going viral : a review of replication-selective oncolytic adenoviruses / Oncotarget 6 : 19976 ~ 19989

  68. [학술지] Rehman H / 2016 / Into the clinic : Talimogene laherparepvec(T-VEC), a first-inclass intratumoral oncolytic viral therapy / J Immunother Cancer 4 : 53

  69. [학술지] Yu Z / 2005 / Enhanced nectin-1 expression and herpes oncolytic sensitivity in highly migratory and invasive carcinoma / Clin Cancer Res 11 : 4889 ~ 4897

  70. [학술지] Mansour M / 2011 / Oncolytic specificity of Newcastle disease virus is mediated by selectivity for apoptosis-resistant cells / J Virol 85 : 6015 ~ 6023

  71. [학술지] Bar S / 2008 / Vesicular egress of non-enveloped lytic parvoviruses depends on gelsolin functioning / PLoS Pathog 4 : e1000126

  72. [학술지] Sova P / 2004 / A tumor-targeted and conditionally replicating oncolytic adenovirus vector expressing TRAIL for treatment of liver metastases / Mol Ther 9 : 496 ~ 509

  73. [학술지] Fulci G / 2006 / Cyclophosphamide enhances glioma virotherapy by inhibiting innate immune responses / Proc Natl Acad Sci U S A 103 : 12873 ~ 12878

  74. [학술지] Yi L / 2016 / CRISPR-Cas9 therapeutics in cancer : promising strategies and present challenges / Biochim Biophys Acta 1866 : 197 ~ 207

  75. [학술지] Yuan M / 2016 / CRISPR-Cas9 as a Powerful Tool for Efficient Creation of Oncolytic Viruses / Viruses 8 : 72

  76. [학술지] Swift SL / 2016 / Big Data Offers Novel Insights for Oncolytic Virus Immunotherapy / Viruses 8

  77. [학술지] Zamarin D / 2014 / Localized oncolytic virotherapy overcomes systemic tumor resistance to immune checkpoint blockade immunotherapy / Sci Transl Med 6 : 226ra232

  78. [학술지] Park YJ / 2016 / Regenerative Applications Using Tooth Derived Stem Cells in Other Than Tooth Regeneration : A Literature Review / Stem Cells Int 2016 : 9305986